User:J. C. Martinez-Garcia/Notebook/HMS Activities/2008/11/15
|The model is almost ready||Main project page|
Previous entry Next entry
On the AKT Model
Today I finish the text and the graphics concerning the model of the modified AKT signaling pathway. In qualitative terms the model is very good, since provides a good explanation of the experimentally observed phenomena. At least the model suggest that the observed behavior is associated to bi-stability. The model does not take into account desensitization and maybe it would be good to say something about this question in the final report of this project. Moreover, the model lies in two strong assumptions:
These two assumptions must be argued in a good way. However, if the model is constrained to be a qualitative description the assumptions are justified. The assumptions opens then a via to new experiments.
I include in here the ZIP file which includes all the figures as well as the LaTeX file and the simulink and mathematica code for the computer-based experiments (Media:AKT_model_sontag.zip).
Tasks for tomorrow