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Intracellular anandamide trafficking as a promoter of neurogenesis acting through presynaptic CB1/FABP binding

The maturation and differentiation of neural stem cells via fatty-acid binding proteins (FABPs) signaling may require anandamide as a promoter of CB1-dependent neurogenesis. [1]

Hippocampal neurogenesis with synaptogenic promoter (DHA) is induced by intracellular and presynaptic CB1 receptor binding to anandamide. [2]


  • The allosteric activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptors) may facilitate hippocampal neurogenesis. (Reference needed)
  • Intracellular FABP5 expression may result in anandamide trafficking of heteromeric CB1 receptor. (Reference needed)
  • Adenosine antagonism (caffeine) may potentiate retrograde trafficking of anandamide via heteromization of CB1 receptor. (Reference needed)
  • Anandamide biosynthesis may enhance caffeine-induced diuresis. [3]
  • Anandamide-oxytocin cross-talk (signal transduction) may modulate cellular stress response/vitamin D gene expression?

See also


  1. [Paper1]

    Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

  2. [Paper2]

    Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.

  3. [Paper3]

    Diuretic Effects of Cannabinoids

  4. [Paper4]

    The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway.

  5. [Paper5]

    The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.