User:Tkadm30/Notebook/Endocannabinoids/2-AG

2-arachidonoylglycerol (2-AG)

Synopsis

• A novel purinergic gliotransmitter controlled by the P2X7 receptor;
• 2-AG is an endocannabinoid ligand synthesized by diacylglycerol lipase (DGL-α) and phospholipase C (PLC).

Notes

• Astrocytes-induced synaptogenesis is enhanced by synaptic retrograde signaling.
• 2-AG synthesis is dependent on arachidonic acid and PLC.
• 2-AG exert neuroprotective effects on excitotoxic brain injury.

See also

• Astrocytes
• Phospholipase C Notebook
• https://en.wikipedia.org/wiki/2-Arachidonoylglycerol