User:Etienne Robillard/Notebook/DHA

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DHA (docosahexaenoic acid)

Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing cAMP/PKA/CREB signaling

  • BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs)
  • Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation via phosphorylation of the NMDA receptor. [1]
    • mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. [2]

Neuroprotective properties of DHA

  • DHA is neuroprotective and controlled by the P2X7 purinoreceptor. [3]
  • DHA exert proneurogenic functions on activated microglia cells. [4]

DHA and vitamin D control of serotonin synthesis

DHEA (N-docosahexaenoyl ethanolamide)

  • Ethanolamide metabolite of DHA.
  • Derivative of anandamide.
  • A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. [5]

DHA-5-HT

  • Serotonin conjugate of DHA. [6]

DHDA

  • Dopamine conjugate of DHA. [7]

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/14622123 [Paper6]
    Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
  2. https://www.ncbi.nlm.nih.gov/pubmed/19812317 [Paper1]
    Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
  3. https://www.ncbi.nlm.nih.gov/pubmed/25504554 [Paper2]
    Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.
  4. https://www.ncbi.nlm.nih.gov/pubmed/22057807 [Paper3]
    Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/ [Paper4]
    Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
  6. https://www.ncbi.nlm.nih.gov/pubmed/27663185 [Paper9]
    Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages.
  7. https://www.ncbi.nlm.nih.gov/pubmed/28292183 [Paper10]
    N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2.
  8. https://www.ncbi.nlm.nih.gov/pubmed/10681412 [Paper5]
    Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels.
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792211/ [Paper7]
    Effects of Docosahexaenoic Acid on Neurotransmission.
  10. https://www.ncbi.nlm.nih.gov/pubmed/16922818 [Paper8]
    Omega-3 fatty acids and hypertension in humans.

See also