User:Etienne Robillard/Notebook/Endocannabinoids/2-AG

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2-arachidonoylglycerol (2-AG)

Synopsis

  • A novel purinergic gliotransmitter controlled by the P2X7 receptor;
  • 2-AG is an endocannabinoid ligand synthesized by diacylglycerol lipase (DGL-α) and phospholipase C (PLC).

Notes

  • Astrocytes-induced synaptogenesis is enhanced by synaptic retrograde signaling.
  • 2-AG synthesis is dependent on arachidonic acid and PLC.
  • 2-AG exert neuroprotective effects on excitotoxic brain injury.

See also