User:Dr. Om V. Singh

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Dr. Om V. Singh (an artistic interpretation)

Dr. Om V. Singh, Associate Professor, University of Pittsburgh, 300 Campus Drive, Bradford, PA-16701, USA

Education

Post-doctoral Fellow– The Johns Hopkins Univ. Sch. Med., Baltimore, MD

M.S.- (Regulatory Affairs in Life Sciences), The Johns Hopkins Univ., Baltimore, MD.

Ph.D.- (Microbial Biotechnology), Indian Institute of Technology (IIT), Roorkee.

M.Sc.- (Zoology, sp.- Entomology), C.C.S. University, Meerut.

B.Sc.- (Biol. Sci.), Merrut University, Merrut.

Research interests

High-dimensional Biology of Radiation-resistant microorganisms (Extremophiles) and therapeutic implications using value added products of commercial significance.

Synthetic biology of antibiotics resistance microbes.

Biosynthesis of Nanoparticles.

Biomass into alternative fuel exploring microorganisms of model invertebrates.

PHARMACOPROTEOMICS OF PROTEIN MISFOLDING (IN COLLABORATION).

Publications

1. Gabani P. and Singh O.V.* (2013) Radiation-resistant extremophiles and their potential in biotechnology and therapeutics. Appl Microbiol Biotechnol 97(3), 512-555. doi: 10.1007/s00253-012-4642-7.

2. Chandel A.K., Antunes F.F.A., Anjos V., Bell M.J.V., Rodrigues L.N., Singh O.V., Silva S.S. (2013) Ultra-structural mapping of oxalic acid fiber expansion (OAFEX) treated sugarcane bagasse for ethanol production by Candida shehatae and Saccharomyces cerevisiae. Biotechnol. Biofuel 6(1), 4. Doi:10.1186/1754-6834-6-4.

3. Upadhyay M., Samal J., Kandpal M., Singh O.V., Vivekanandan P. (2013) Warburg effect: insights from the past decade. Pharmacology & Therapeutics. 137(3), 318-330. doi: 10.1016/j.pharmthera.2012.11.003.

4. Prakash D., Gabani P., Kumar A.K., Ronen Z., Singh OV.* (2013) Bioremediation: a genuine technology to remediate radionuclides from the environment. Microbial Biotechnol. Doi: 10.1111/1751-7915.12059.

5. Chandel A.K., da Silva S.S. and Singh O.V.* (2013) Detoxification of lignocellulose hydrolysates: Metabolic engineering towards the advancement of White Biotechnology. BioEnergy Research 6, 388-401. DOI 10.1007/s12155-012-9241-z.

6. Woappi Y.L., Gabani P. and Singh O.V.* (2013) Emergence of antibiotic-producing microorganisms in residential versus recreational microenvironments. British J of Microbiol Research 3(3), 280-294.

7. Gabani P., Copeland E., Chandel A.K. and Singh O.V.* (2012) Ultraviolet-radiation-resistant extremophiles and polyextremophiles revealed cellulose-degrading species of Cellulosimicrobium cellulans-UVP1 and Bacillus pumilus-UVP4. Biotechnol Appl Biochem 59(5), 395-404.

8. Gabani P., Prakash, D. and Singh O.V.* (2012) Emergence of Antibiotic-resistance Extremophiles. Extremophiles 16(5), 697-713.

9. Chandel A.K., Carvalho W., da Silva S.S., Singh O.V.* (2012) Sugarcane bagasse and leaves: Foreseeable biomass of biofuel and bio-products. J. Chem Technol Biotechnology, 87, 11-20.

10. Singh O.V. and Tao Y.X. (2012) Two-dimensional gel electrophoresis: discovering neuropathic pain-associated synaptic biomarkers in spinal cord dorsal horn. Methods Mol Biol. 851, 47-63.

11. Singh O.V.* and Gabani P. (2011) Therapeutic implications of Radiation-resistant Extremophiles. J Applied Microbiology, 110(4), 851-861.

12. Chandel A.K., and Singh O.V.* (2011) Weedy lignocellulosic feedstock and Metabolic Engineering: Advancing the generation of ‘Biofuel’. Applied Microbiology Biotechnology. 89(5), 1289-1303.

13. Chandel A.K., Singh O.V., Rao L.V., Chandrasekhar G, Narasu M.L. (2011) Bioconversion of novel substrate Saccharum spontaneum, a weedy material, into ethanol by Pichia stipitis NCIM3498. Bioresource Technology 102(2) 1709-1714.

14. Chandel A.K., Singh O.V., Narasu M.L., Rao L.V. (2011) Bioconversion of Saccharum spontaneum (wild sugarcane) hemicellulosic hydrolysate into ethanol by mono and co-cultures of Pichia stipitis NCIM3498 and thermotolerant Saccharomyces cerevisiae-VS3. New Biotechnol. 28(6), 593-599.

15. Singh O.V.* and Colonna T.E. (2011) Prescription drug reimportation in the United States: Friend or foe. Pharmaceutical Technol. 35(2) 97-88.

16. Singh O.V.* and Colonna T.E. (2011) The impasse over US drug reimportation may be a blessing in disguise. Regulatory Affairs Pharma, 6 January 2011.

17. Singh O.V.* and Colonna T.E. (2011) Perspective and regulations of prescription drug reimportation in the United States. Studies in Ethics, Law, and Technology (In press).

18. Nagaraj N.S. and Singh, O.V.* (2010) Using genomics to develop novel antibacterial therapeutics. Critical Review Microbiology, 36(4) 340-348.

19. Singh O.V.* (2010) Protein misfolding diseases and paradigm of proteomics based therapeutic targets. Expert Review of Proteomics. Editorial comment 7(4), 463-4.

20. Handerson, M., Singh O.V., Zeitlin P.L. (2010) Applications of proteomic technology to premature proteolysis of CFTR in cystic fibrosis. Expert Review of Proteomics 7(4), 473-86.

21. Nagaraj, N.S. and Singh O.V. (2010) Proteomics: A strategies to understand the novel targets in protein misfolding and cancer therapy. Expert Review of Proteomics 7(4), 613-23.

22. Vivekanandan P. and Singh, O.V. (2010) Molecular methods in the diagnosis and management of chronic hepatitis B. Expert Review of Molecular Diagnostics, 10(7) 921-935.

23. Nagaraj N.S., Anilakumar K.R., Singh O.V. (2010) Diallyl disulfide cause caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway. J Nutritional Biochemistry, 21(5): 405-412.

24. Chandel A.K., Singh O.V., Chandrasekhar G., Rao L.V., Narasu M.L. (2010) Key-drivers influencing the commercialization of ethanol-based biorefineries. J. of Commercial Biotechnology, 16, 239-257. DOI:10.1057/jcb.2010.5

25. Singh, O.V.* and Chandel A.K. (2010) Two dimensional gel electrophoresis: Discovering biomolecules for environmental bioremediation. Methods Molecular Biology, 599: 141-56.

26. Singh O.V.* (2010) Perspectives of patent infringement and pharmaceutical drug development. Regulatory Affairs Pharma , 20 July, 415-416.

27. Singh O.V.* (2010) Regulatory and safety assessments of genetically engineered food. Studies in Ethics, Law, and Technology 4(1), Article 2. DOI: 10.2202/1941-6008.1100.

28. Singh O.V., Yaster M., Guan Y., Dharmarajan A.M., Raja S.N., Zeitlin P.L. and Tao Y-X (2009) Peripheral nerve injury modulated proteome of synaptosome-associated proteins in spinal cord dorsal horn. Proteomics 9(5): 1241-1253.

29. Nagaraj N.S., Singh, O.V.* (2009) Integrating Omics oriented Biomarkers to comprehend lung cancer. Expert Opinion on Medical Diagnostics 3(2): 167-180.

30. Singh O.V.*, Harvey S.P. (2008) Integrating biological processes to facilitate the generation of ‘Biofuel’. J Industrial Microbiology and Biotechnology (Editorial comment) 35(5): 291-2. PMID: 18347827.

31. Singh, O.V.* (2008) Modulated gluconic acid production from immobilized cells of Aspergillus niger ORS-4.410 utilizing grape must. J. Chemical Tech. Biotechnol. 83(6): 780-787.

32. Kumar R., Singh S and Singh O.V. (2008) Bioconversion of lignocellulosic biomass: Biochemical and molecular perspectives. J Industrial Microbiology and Biotechnology. 35(5): 377-91. PMID: 18338189

33. Chandel, A.K., Rao, L.V., Rudravaram, R. and Singh, O.V.* (2008) The realm of Penicillin G Acylase in β-lactam antibiotics. Enzyme Microbial Technology 42(3): 199-207.

34. Singh, O.V., Pollard, H.B. and Zeitlin, P.L. (2008) Chemical rescue of ∆F508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells. Molecular Cellular Proteomics 7(6): 1099-110. PMID: 18285607

35. Perumal V. and Singh O.V.* (2008) High-Dimensional Biology to comprehend Hepatocellular carcinoma. Expert Review of Proteomics 5(1): 45-60. PMID: 18282123

36. Nagaraj N.S. and Singh O.V. (2007) Proteomic and Genomic Analysis of Human Tumor Cells Treated with Diallyl Disulfide. J. Nutr. 137, 278S-295S.

37. Singh O.V.* and Kumar R. (2007) Biotechnological production of gluconic acid: Future Implications. Appl. Microbiol. Biotechnol. 75(4), 713-722. PMID: 17525864

38. Singh O.V.* (2007) Integrating “-omics” into biological processes and modeling for bioremediation. OMICS: A Journal of Integrative Biology (Editorial Comment) 11(3), 231-232. PMID: 17883336

39. Kumar, R., Singh, S and Singh, O.V. (2007) Bioremediation of toxic Radionuclides: Emerging technologies. OMICS: A Journal of Integrative Biology, 11(3) 295-304. PMID: 17883340

40. Singh O.V., Vij N., Mogayzel P., Jozwik C., Pollard H.B and Zeitlin P.L (2006) Pharmacoproteomics of 4-Phenylbutyrate-treated IB3-1 cystic fibrosis bronchial epithelial cells. J Proteome Research, 5 (3), 562-571. PMID: 16512671

41. Singh O.V* (2006) Proteomics and Metabolomics: The Molecular make up of toxic aromatic pollutant bioremediation. Proteomics, 6 (20), 5481-5492. PMID: 16972298

42. Singh O.V* and Nagaraj N.S (2006) Transcriptomics, Proteomics and Interectomics: Unique approaches to track the insights of Bioremediation. Brief. Functional Genomics Proteomics, 4 (4), 355-365. PMID: 17202126

43. Singh O.V.* (2006) Mutagenesis and analysis of mold Aspergillus niger for extracellular glucose oxidase production using sugarcane molasses. Appl. Biochem. Biotechnol., 135(1), 43-58. PMID: 17057255

44. Singh O.V and Singh R.P (2006) Bioconversion of grape must into modulated gluconic acid production by Aspergillus niger ORS-4.410. J. Appl. Microbiol., 100 (5), 1114- 1122. PMID: 16630012

45. Singh O.V., Ghai, S., Paul, D and Jain R.K. (2006). Genetically Modified Crops: Success, Safety assessment and public concern. Appl. Microbiol. Biotechnol., 71 (5), 598-607. PMID: 16639559

46. Labana S., Singh O.V., Basu A., Pandey G and Jain R.K (2005) A microcosm study on bioremediation of p-nitrophenol contaminated soil using Arthrobacter protophormiae RKJ100. Appl. Microbiol. Biotechnol., 68 (3), 417-424. PMID: 15806356

47. Singh O. V, Kapur N and Singh R.P (2005) Evaluation of agro-food byproducts for gluconic acid fermentation by Aspergillus niger ORS-4.410. World J Microbiol. Biotechnol., 21 (4), 519-524. 48. Singh, O.V and Jain R.K (2003). Phytoremediation of toxic aromatic pollutants from soil. Appl. Microbiol. Biotechnol., 63(2), 128-35. PMID: 12925865.

49. Singh, O.V., Gunjan P., Budhiraja R. and Jain R.K. (2003). Phytoremediation: An overview on metallic ions decontamination from soil. Appl. Microbiol. Biotechnol., 61, (5-6), 405-412. PMID: 12764555

50. Singh, O.V., Jain R.K. and Singh R.P. (2003). Gluconic acid production under varying fermentation conditions by Aspergillus niger. J Chemical Technol. Biotechnol., 78, (2-3), 208-212.

51. Singh, O.V. and Singh R.P. (2003). Utilization of grape must for gluconic acid production using polyurethane sponge and calcium alginate immobilized cells of Aspergillus niger ORS-4.410. Commun Agric Appl Biol Sci., 68 (2 Pt A): 253. PMID: 15296173

52. Samanta, S.K., Singh, O.V and Jain, R.K. (2002). Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation. Trends in Biotechnology, 20 (6), 243-248. PMID: 12007492

53. Singh, O.V. and Singh, R.P (2002). Utilization of agro-food by-products for gluconic acid production by Aspergillus niger ORS-4 under surface culture cultivation. J Sci. Ind. Res., 61, 356-360.

54. Singh, O.V. and Singh, R.P. (2002). Microbial production of glucose oxidase by Aspergillus niger. Proc. 5th Asia Pacific Cong. Med. Biol. Eng. & 11th Int. Cong. Biomed. Eng. Singapore.

55. Singh, O.V., Gunjan, P and Jain, R.K. (2001). Bioremediation of p-nitrophenol using soil microcosm. Proc. Int. Conf. Remediation of Contaminated Sediments. Venice, Italy. (on CD)

56. Singh, O.V., Sharma, A and Singh, R.P (2001). Optimisation of fermentation conditions for gluconic acid production by mutant Aspergillus niger. Indian J Exp. Biol., 39, 1136-1143. PMID: 11906107

57. Singh, O.V., Sharma, A and Singh, R.P (2001). Gluconic acid production by Aspergillus niger mutant ORS-4.410 in submerged and solid state surface cultivation. Indian J Exp. Biol., 39, 691-696. PMID: 12019764

58. Singh, O.V., Pereira, B.M.J and Singh, R.P (1999). Isolation and characterization of a potent fungal strain Aspergillus niger ORS-4 for gluconic acid production. J Sci. Ind. Res., 58, 594-600.

59. Singh, O.V and Verma, S.R (1997). Factors affecting citric acid production by Aspergillus niger in submerged culture. J Natcon, 9 (1); 1-7.

(*Corresponding author)

Book Chapters:

1. Copeland E., Choy, N. and Singh, O.V* (2012) Microbial biosynthesis of Extremolytes and Extremozymes: Biotechnological implications. Extremophiles: Sustainable resources and Biotechnological Implications, Ed. Singh O.V., The Johns Wiley and Sons Ltd. Publisher, pp. 367-388.

2. Chandel, A.K., Giese, E., Singh, O.V and da Silva SS (2012) The role of extremophiles in biorefinery: current status and future perspectives. Extremophiles: Sustainable resources and Biotechnological Implications, Ed. Singh O.V., The Johns Wiley and Sons Ltd. Publisher, pp. 267-289.

3. Mpabanga T.P., Chandel A.K., Silva S.S. and Singh O.V.* (2012) Detoxification strategies applied to lignocellulosic hydrolysates for improved xylitol production. Xylitol Biotechnology, Eds. Silva S.S., Chandel A.K., Springer Press, pp.63-82.

4. Singh, O.V.*, Nagaraj N.S. and Gabani, P (2011) System Biology: Integrating ‘-omics” oriented approaches to determine microbial toxins. System Toxicology: From Omics Technology to Nanotechnology”, Eds. Sahu SC and Casciano DA., The John Wiley and Sons Ltd. Publisher, pp469-488.

5. Chandel A.K., da Silva SS. and Singh OV* (2011) Detoxification of lignocellulosic hydrolysates for improved bioconversion of bioethanol. Biofuel, Ed. P. Zobic InTech Publisher. ISBN 978-953-307-178-7.

6. Singh O.V.* and Harvey S.P. (2010) Applications of Biotechnology for the Utilization of Renewable Energy Resources. Sustainable Biotechnology: Sources of Renewable Energy. (Editorial comment) Eds. Singh, O.V. and Harvey S.P., Springer press UK, pp. xiii-xvii.

7. Chandel, A.K., Singh O.V and Rao L.V. (2010) Biotechnological applications of Hemicellulosic derived sugars: State-of-the art. Biotechnology and Sustainable source of energy. Eds. Singh, O.V. and Harvey S.P., Springer press UK, pp. 63-81.


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