I am a new member of OpenWetWare!
- Divya Sitaraman
- University of San Diego
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- Email me through OpenWetWare
I work in the Your Lab at XYZ University. I learned about OpenWetWare from Colleagues and friends, and I've joined because I am scientists interested in how organisms generate behavior and survive in the natural world. In trying to understand this I read, search and research. I want to join OWW to add my knowledge and gain from the available resources..
Associate Research Scientist, Dept of Cellular and Molecular Physiology, Yale University (2010-14) Postdoctoral Research, Janelia Research Campus at Howard Hughes Medical Institution (2011-14)
PhD, Biological Sciences (Neurobiology and Behavior), University of Missouri, 2010 MS, Biotechnology, Indian Institute of Technology, India, 2003 BS, Biochemistry, University of Delhi, 2001
As a neuroscientist Dr. Sitaraman has had a long standing interest in an organism’s ability to interact with its environment, evaluate choices and produce behavioral outputs. In addressing these complex processes the Sitaraman lab focuses on small circuits with measurable behavioral outputs in organisms that can be genetically manipulated.
The specific research interests of the Sitaraman lab are as follows:
Innate and learned behaviors: Nervous system plasticity is best manifested at the level of behaviors. An important focus area in the lab is to develop and validate novel classical and operant learning paradigms. In addition to developing these paradigms, the lab has an active interest in studying innate behaviors such as sleep and arousal.
Genetic basis of behavior: A variety of neurogenetic techniques in the context of learning and sleep have identified neurotransmitter and neuropeptide modulators that underlie these behaviors. Beyond these modulatory signals, circuit level interpretation of behavior in Drosophila is severely lacking. As a first step in cracking the neuronal pathways underlying the sleep circuit, the lab is invested in identifying the individual neurons of the circuit. To this end Dr. Sitaraman has an active collaboration with Dr. Michael Nitabach at Yale University and Dr. Gerry Rubin at Janelia Research Campus (Janelia Visitor Project 2014-2015) to develop and test cell specific tools in the context of sleep regulation.
Cellular/ Circuit level dynamics of behavior: Cellular excitability and synaptic function in behavioral control networks of the fly can only be addressed with novel imaging and electrophysiological approaches. Using validated calcium imaging and novel voltage imaging approaches in Drosophila the Sitaraman lab hopes to identify the properties of synaptic connectivity and plasticity underlying innate and learned behaviors.
- Goldbeter A and Koshland DE Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4.
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56.
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