User:Alex S. Nord

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Alex S. Nord (an artistic interpretation)


  • 2011, PhD, University of Washington
  • 2001, BA, Carleton College

Research interests

  1. Genetic contribution to complex phenotypes
  2. Identification and function of regulatory DNA
  3. Relationship between genetic variation and human disease


  1.  : Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ,

    Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci U S A. 2011 Oct 17. PubMed PMID: 22006311.

    2: Nord AS, Lee M, King MC, Walsh T. Accurate and exact CNV identification from

    targeted high-throughput sequence data. BMC Genomics. 2011 Apr 12;12:184. PubMed PMID: 21486468; PubMed Central PMCID: PMC3088570.

    3: Nord AS, Roeb W, Dickel DE, Walsh T, Kusenda M, O'Connor KL, Malhotra D,

    McCarthy SE, Stray SM, Taylor SM, Sebat J; STAART Psychopharmacology Network, King B, King MC, McClellan JM. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. Eur J Hum Genet. 2011 Jun;19(6):727-31. Epub 2011 Mar 30. PubMed PMID: 21448237; PubMed Central PMCID: PMC3110052.

    4: Ronald J, Rajagopalan R, Cerrato F, Nord AS, Hatsukami T, Kohler T, Marcovina

    S, Heagerty P, Jarvik GP. Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk. Stroke. 2011 Jan;42(1):2-9. Epub 2010 Dec 2. PubMed PMID: 21127300; PubMed Central PMCID: PMC3020902.

    5: Gaynor JW, Gerdes M, Nord AS, Bernbaum J, Zackai E, Wernovsky G, Clancy RR,

    Heagerty PJ, Solot CB, McDonald-McGinn D, Jarvik GP. Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy? J Thorac Cardiovasc Surg. 2010 Dec;140(6):1230-7. Epub 2010 Oct 15. PubMed PMID: 20951391.

    6: Walsh T, Lee MK, Casadei S, Thornton AM, Stray SM, Pennil C, Nord AS, Mandell

    JB, Swisher EM, King MC. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12629-33. Epub 2010 Jun 28. PubMed PMID: 20616022; PubMed Central PMCID: PMC2906584.

    7: Walsh T, Pierce SB, Lenz DR, Brownstein Z, Dagan-Rosenfeld O, Shahin H, Roeb

    W, McCarthy S, Nord AS, Gordon CR, Ben-Neriah Z, Sebat J, Kanaan M, Lee MK, Frydman M, King MC, Avraham KB. Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. Am J Hum Genet. 2010 Jul 9;87(1):101-9. Epub 2010 Jun 17. PubMed PMID: 20602916; PubMed Central PMCID: PMC2896780.

    8: Shahin H, Walsh T, Rayyan AA, Lee MK, Higgins J, Dickel D, Lewis K, Thompson

    J, Baker C, Nord AS, Stray S, Gurwitz D, Avraham KB, King MC, Kanaan M. Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families. Eur J Hum Genet. 2010 Apr;18(4):407-13. Epub 2009 Nov 4. PubMed PMID: 19888295; PubMed Central PMCID: PMC2987250.

    9: Chen J, Zimmerman RA, Jarvik GP, Nord AS, Clancy RR, Wernovsky G, Montenegro

    LM, Hartman DM, Nicolson SC, Spray TL, Gaynor JW, Ichord R. Perioperative stroke in infants undergoing open heart operations for congenital heart disease. Ann Thorac Surg. 2009 Sep;88(3):823-9. PubMed PMID: 19699905; PubMed Central PMCID: PMC2840405.

    10: Gaynor JW, Nord AS, Wernovsky G, Bernbaum J, Solot CB, Burnham N, Zackai E,

    Heagerty PJ, Clancy RR, Nicolson SC, Jarvik GP, Gerdes M. Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery. Pediatrics. 2009 Jul;124(1):241-50. PubMed PMID: 19564306; PubMed Central PMCID: PMC2840402.

    11: Fuller S, Nord AS, Gerdes M, Wernovsky G, Jarvik GP, Bernbaum J, Zackai E,

    Gaynor JW. Predictors of impaired neurodevelopmental outcomes at one year of age after infant cardiac surgery. Eur J Cardiothorac Surg. 2009 Jul;36(1):40-7. Epub 2009 Apr 25. PubMed PMID: 19394849.

    12: Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R,

    Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL. Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. J Lipid Res. 2009 May;50(5):798-806. Epub 2009 Jan 5. PubMed PMID: 19124843; PubMed Central PMCID: PMC2666166.

    13: Noetzli LJ, Carson SM, Nord AS, Coates TD, Wood JC. Longitudinal analysis of

    heart and liver iron in thalassemia major. Blood. 2008 Oct 1;112(7):2973-8. Epub 2008 Jul 23. PubMed PMID: 18650452; PubMed Central PMCID: PMC2556627.

    14: Goode EL, Fridley BL, Sun Z, Atkinson EJ, Nord AS, McDonnell SK, Jarvik GP,

    de Andrade M, Slager SL. Comparison of tagging single-nucleotide polymorphism methods in association analyses. BMC Proc. 2007;1 Suppl 1:S6. Epub 2007 Dec 18. PubMed PMID: 18466560; PubMed Central PMCID: PMC2367496.

    15: Reiner AP, Wurfel MM, Lange LA, Carlson CS, Nord AS, Carty CL, Rieder MJ,

    Desmarais C, Jenny NS, Iribarren C, Walston JD, Williams OD, Nickerson DA, Jarvik GP. Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1407-12. Epub 2008 May 1. PubMed PMID: 18451331; PubMed Central PMCID: PMC2748384.

    16: Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov

    V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, Nelson SF, Singleton AB, Lee MK, Rapoport JL, King MC, Sebat J. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science. 2008 Apr 25;320(5875):539-43. Epub 2008 Mar 27. PubMed PMID: 18369103.

    17: Tabbutt S, Nord AS, Jarvik GP, Bernbaum J, Wernovsky G, Gerdes M, Zackai E,

    Clancy RR, Nicolson SC, Spray TL, Gaynor JW. Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome. Pediatrics. 2008 Mar;121(3):476-83. PubMed PMID: 18310195.

    18: Zeltser I, Jarvik GP, Bernbaum J, Wernovsky G, Nord AS, Gerdes M, Zackai E,

    Clancy R, Nicolson SC, Spray TL, Gaynor JW. Genetic factors are important determinants of neurodevelopmental outcome after repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2008 Jan;135(1):91-7. PubMed PMID: 18179924.

    19: Crawford DC, Nord AS, Badzioch MD, Ranchalis J, McKinstry LA, Ahearn M,

    Bertucci C, Shephard C, Wong M, Rieder MJ, Schellenberg GD, Nickerson DA, Heagerty PJ, Wijsman EM, Jarvik GP. A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk. J Lipid Res. 2008 Mar;49(3):588-96. Epub 2007 Dec 3. PubMed PMID: 18056683.

    20: Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y,

    Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One. 2007 Jul 18;2(7):e617. PubMed PMID: 17637833; PubMed Central PMCID: PMC1910612.

    21: Gaynor JW, Wernovsky G, Jarvik GP, Bernbaum J, Gerdes M, Zackai E, Nord AS,

    Clancy RR, Nicolson SC, Spray TL. Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery. J Thorac Cardiovasc Surg. 2007 May;133(5):1344-53, 1353.e1-3. Epub 2007 Mar 19. PubMed PMID: 17467455; PubMed Central PMCID: PMC2844117.

    22: Carlson CS, Heagerty PJ, Nord AS, Pritchard DK, Ranchalis J, Boguch JM, Duan

    H, Hatsukami TS, Schwartz SM, Rieder MJ, Nickerson DA, Jarvik GP. TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects. Hum Genet. 2007 Mar;121(1):65-75. Epub 2006 Nov 18. PubMed PMID: 17115186.

    23: Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns

    SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D642-8. PubMed PMID: 16381950; PubMed Central PMCID: PMC1347459.

    24: Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz

    P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J; International Gene Trap Consortium. A public gene trap resource for mouse functional genomics. Nat Genet. 2004 Jun;36(6):543-4. PubMed PMID: 15167922; PubMed Central PMCID: PMC2716026.


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