Smolke:Research: Difference between revisions

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Engineered biological systems that process information, materials, and energy hold great promise for developing solutions to many global challenges, including energy and food production, materials synthesis, and medical advancement. Our ability to engineer biological systems is limited by the foundational tools available for programming cellular behavior (i.e., getting information into and acting on information in living systems) and our understanding of how such systems should be constructed (i.e., probing and accessing information in living systems). By developing genetically encoded technologies for reporting on, responding to, and controlling intracellular components in living systems, we are addressing prominent challenges faced in basic and applied biological research. Our research efforts focus on the design of new molecular tools for performing information processing, computation, and control functions in living systems and the application of these tools to programming biological systems. The resulting advances in our ability to transmit information to and from living systems and implement control within cells themselves, will broadly transform how we interact with and program biology, providing access to otherwise inaccessible information on cellular state and allowing sophisticated exogenous and embedded control over cellular functions.  
Engineered biological systems that process information, materials, and energy hold great promise for developing solutions to many global challenges, including energy and food production, materials synthesis, and medical advancement. Our ability to engineer biological systems is limited by the foundational tools available for programming cellular behavior (i.e., getting information into and acting on information in living systems) and our understanding of how such systems should be constructed (i.e., probing and accessing information in living systems). By developing genetically encoded technologies for reporting on, responding to, and controlling intracellular components in living systems, we are addressing prominent challenges faced in basic and applied biological research. Our research efforts focus on the design of new molecular tools for performing information processing, computation, and control functions in living systems and the application of these tools to programming biological systems. The resulting advances in our ability to transmit information to and from living systems and implement control within cells themselves, will broadly transform how we interact with and program biology, providing access to otherwise inaccessible information on cellular state and allowing sophisticated exogenous and embedded control over cellular functions.  


==Engineering RNA device platforms as programmable sensing-actuation devices==
=Component and Device Engineering=
==Engineering RNA-based cellular information processing, communication, and control devices==
''Researchers: Ryan Bloom, Drew Kennedy, Jay Vowles, Josh Wolf''
''Researchers: Ryan Bloom, Drew Kennedy, Jay Vowles, Josh Wolf''


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