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               <h2> Please visit our new website at <a href=""></a></h2></div>

<h1> <span style="text-transform: uppercase">Systems Biology of Human Diseases</span> Laboratory</h1>

<div id="menu"> <ul id="main"> <li><a href="">Home</a></li> <li><a href="">Lab Members</a></li> <li><a href="">Publications</a></li> <li><a href="">Research Interests</a></li>

                       <li><a href="">Patents</a></li>
                       <li><a href="">Courses</a></li>
                       <li><a href="">Pictures</a></li>

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Recent Lab News

December 2010 Dr. Nagrath's article in the journal "Tissue Engineering Part A" entitled "Three dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel" is among the list of 20 of the most cited articles from 2008-2009.

December 2010 Dr. Nagrath has joined to the editorial board of journal "Journal of Biosensor and Bioelectronics".

November 2010 Congratulations to our newest lab members: Aaron Damm, Lifeng Yang, Bahar Salimian, first year chemical engineering graduate students!

November 2010 Congratulations to Christine Caneba for receiving 2010 Edgar O'Rear Travel Grant.

July 2010 Congratulations to Professor Nagrath's lab and Professor Grande-Allen's lab (BIOE, RICE) for receiving the Hamill Innovations Award

July 2010 Dr. Nagrath and Dr. Wong (BME, CUNY) publish book chapter entitled Liver Tissue Engineering in Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends

May 2010 Congratulations to new group member Christine Caneba (Bioengineering, II year) on joining the group.

May 2010 Professor Deepak Nagrath's paper Soft Constraints-Based Multiobjective Framework for Flux Balance Analysis. is accepted for publication in THE Metabolic Engineering JOURNAL.

March 2010 Professor Deepak Nagrath's research in adipocytes and discovery of natural extracellular matrix has been featured in several science-related websites.

February 2010 Professor Deepak Nagrath's paper Adipocyte Derived Basement Membrane Extract With Biological Activity: Applications in Hepatocyte Functional Augmentation In vitro. is accepted for publication in THE FASEB JOURNAL.

Met eng.jpg September 2009 Professor Deepak Nagrath's research in tissue engineering and metabolic engineering is highlighted as cover article. An article entitled "Metabolic Preconditioning of Donor Organs: Defatting Fatty Livers by Normothermic Perfusion Ex Vivo" appears on the cover of the August/September 2009 issue of Metabolic Engineering.

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Research Interests

- Network Systems Biology

- Nutritional Systems Biology

- Cellular Reprogramming into Embryonic Stem Cells

- Disease Systems Biology

- Cancer Metabolism

- Cellular and Metabolic Tissue Engineering

The Systems Biology of Human Diseases Laboratory is focused on both experimental and theoretical aspects in the area of Cellular and Molecular Tissue Engineering, Metabolic Engineering, and Biomedicince with emphasis on clinical applications. Our research interests lie in the application of nutritional systems-biology approaches in highly challenging, cutting edge problems in clinical disciplines such as metabolic syndrome, liver fibrosis, and regenerative medicine. Nutritional Systems Biology (NSB) is defined as the approach to understand the key processes that regulate metabolism at all levels of complexity and to predict the outcome of any alteration of the system by utilizing metabolic tools. We use transcriptional and metabolic design principles to analyze healthy and diseased biological states. His research focuses on various diseases such as metabolic syndrome, cancer, and diabetes, and potential treatments using metabolic supplementation and embryonic stem cells. Dr. Nagrath makes a concerted effort to use engineering principles, such as multiobjective optimality and nonequilibrium thermodynamics, for analyzing complex disease states. His research integrates both experimental and theoretical tools to develop a recipe for maintaining normal function of various organs. The goal of his work is to offer an important window to understand the role of environmental stress/factors interactions with the cellular components, and in modulating those interactions optimally to improve human health. In an effort towards understanding the energetic basis of embryonic stem cells (ESC) transcriptional network, Professor Nagrath is focusing on developing framework that can predict the abundance of topological motifs in the transcriptional regulatory network using combined thermodynamics and Pareto optimality analysis.

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