Hernan Lopez-Schier

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File:Neurons.tif Research Unit Sensory Biology & Organogenesis

Helmholtz Zentrum München

Ingolstädter Landstrasse 1 85764 Neuherberg - Munich,

Germany


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Our group focuses on understanding the fundamental principles that govern the development of tissue and organs in vertebrates, and to define the cellular, molecular and physiological bases underlying the acquisition and maintenance of sensory-organ function. We employ genetic, electrophysiological and molecular approaches and state-of-the-art optical imaging techniques to study sensory physiology and the formation and remodelling of neuroepithelial architecture, organ repair and regeneration. Our studies aim at providing fundamental insight into how sensory organs develop and regenerate, and how their organization and function are maintained throughout life.

Professional Career

  • 1996, Guest Student, The Rockefeller University, NY, USA
  • 1997-2001, PhD, Wellcome CR-UK, University of Cambridge, UK
  • 2002-2006, Postdoc, The Rockefeller University, NY, USA
  • 2006-2011, Junior Group Leader, Centre for Genomic Regulation, Barcelona, Spain
  • 2011-2012, Group Leader, Centre for Genomic Regulation, Barcelona, Spain
  • 2012-present, SBO Research Unit Director, HMGU, Munich, Germany

Research interests

  1. Mechanosensory Biology
  2. Tissue Mechanics
  3. Organogenesis & Regeneration

Publications

  1. López-Schier, H., Starr, C., Kappler, J.A., Kollmar, R. and Hudspeth, A.J. ″Directional cell migration establishes
         the axes of planar polarity in the posterior lateral-line organ of the zebrafish″
    

    Developmental Cell 7: 401–412, 2004 http://www.ncbi.nlm.nih.gov/pubmed/15363414

    [Paper1]
  2. Faucherre, A., Pujol-Martí, J., Kawakami, K. and López-Schier, H.
        ″Afferent neurons of the zebrafish lateral line are strict selectors of hair-cell orientation″
         PLoS ONE 4 (2): e4477, 2009   http://www.ncbi.nlm.nih.gov/pubmed/19223970
    
    [Paper2]
  3. Faucherre, A., Baudoin, J-P., Pujol-Martí, J. and López-Schier, H.
        ″Multispectral four-dimensional imaging reveals that evoked activity modulates peripheral arborization
         and the selection of plane-polarized targets by sensory neurons″
        Development 137(10): 1635-1643, 2010  http://www.ncbi.nlm.nih.gov/pubmed/20430744
    
    [Paper3]
  4. Swoger, J., Muzzopappa, M., López-Schier, H., and Sharpe, J.
        ″4D retrospective lineage tracing using SPIM for zebrafish organogenesis studies″
         Journal of Biophotonics, 4(1-2):122-34, 2011  http://www.ncbi.nlm.nih.gov/pubmed/20925108
    
    [Paper4]
  5. Wibowo, I., Pinto-Texeira, F., Satou, C., Higajishima, S-i., and López-Schier, H.
         ″Compartmentalized Notch signaling sustains epithelial mirror symmetry″
          Development 138(6):1143-52, 2011  http://www.ncbi.nlm.nih.gov/pubmed/21343366
    
    [Paper5]
  6. Pujol-Martí, J., Zecca, F., Baudoin, J-P., Faucherre, A., Asakawa, K., Kawakami, K. and López-Schier, H.
         ″Neuronal birth order identifies a dimorphic sensorineural map″
          Journal of Neuroscience 32(9):2976-87, 2012 http://www.ncbi.nlm.nih.gov/pubmed/22378871
    
    [Paper6]

Links to Colleagues Homepages

  • A. James Hudspeth [[1]]
  • Alain Ghysen [[2]]