Bitan:Notebook/Role of Met in amyloid beta induced neurotoxicity

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The assembly of amyloid β-protein (Aβ) into oligomers and fibrils is thought to be a key causative event in Alzheimer’s disease (AD). Methionine 35 (Met35) plays a significant role in stabilization of Aβ-oligomers and neurotoxicity. Oxidation of Met35 to sulfoxide ([Met(O)35]Aβ) has been shown to delays Aβ assembly and decreases neurotoxicity.

This project is interested to know (1)The role of Met35 in redox reaction with substituting by Norleucine or valine and their structure activity relationship study (2) oxidation of Met35 to sulfoxide or sulfone and their structure function relationship study