Difference between revisions of "Wikiomics:PSI-BLAST"
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Revision as of 20:00, 19 November 2007
PSI-BLAST - Position-Specific Iterated BLAST. Variant of BLAST used for disovery of weak but relevant protein sequence matches. The algorithm is based on running consequitive BLAST searches using position weight matices:
- query sequence ->
- first blast search ->
- first iteration blast results ->
- sequence alignment of strong matches ->
- creating a profile #1 ->
- second iteration blast search with profile #1 as a query ->
- second iteration blast results, etc.
PSI-BLAST server at NCBI: link