User:Wiep Klaas Smits

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Wiep Klaas Smits

Contact Info

Wiep Klaas Smits
Department of Biology
Building 68-540D
77 Massachusetts Ave
Cambridge MA 02139

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  • 2007, PhD, University of Groningen, The Netherlands, cum laude
  • 2002, MSc, University of Groningen, The Netherlands, cum laude
  • 1998, Propedeuse (undergraduate degree), University of Groningen, The Netherlands, cum laude

Research interests

  1. Interest 1
  2. Interest 2
  3. Interest 3

Awards and honours

  • 2008, Rubicon Fellowship from the Netherlands Organisation for Scientific Research
  • 2007, EMBO Long Term Fellowship (declined)
  • 2007, Nat L. Sternberg Thesis Prize, for the most outstanding PhD thesis in the field of prokaryotic molecular genetics
  • 2005, Kiem Prize of the Dutch Society of Microbiology (NVvM), for the best first publication as a first author


  1. Smits WK, Goranov AI, and Grossman AD. Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo. Mol Microbiol. 2010 Jan;75(2):452-61. DOI:10.1111/j.1365-2958.2009.06999.x | PubMed ID:19968790 | HubMed [Paper1]
  2. Kovács AT, Smits WK, Mirończuk AM, and Kuipers OP. Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries. Environ Microbiol. 2009 Aug;11(8):1911-22. DOI:10.1111/j.1462-2920.2009.01937.x | PubMed ID:19453701 | HubMed [Paper2]
  3. Veening JW, Smits WK, and Kuipers OP. Bistability, epigenetics, and bet-hedging in bacteria. Annu Rev Microbiol. 2008;62:193-210. DOI:10.1146/annurev.micro.62.081307.163002 | PubMed ID:18537474 | HubMed [Paper3]
  4. Lulko AT, Veening JW, Buist G, Smits WK, Blom EJ, Beekman AC, Bron S, and Kuipers OP. Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis. Appl Environ Microbiol. 2007 Aug;73(16):5354-62. DOI:10.1128/AEM.00472-07 | PubMed ID:17586671 | HubMed [Paper4]
  5. Smits WK, Bongiorni C, Veening JW, Hamoen LW, Kuipers OP, and Perego M. Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis. Mol Microbiol. 2007 Jul;65(1):103-20. DOI:10.1111/j.1365-2958.2007.05776.x | PubMed ID:17581123 | HubMed [Paper5]
  6. Smits WK, Hoa TT, Hamoen LW, Kuipers OP, and Dubnau D. Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein. Mol Microbiol. 2007 Apr;64(2):368-81. DOI:10.1111/j.1365-2958.2007.05662.x | PubMed ID:17493123 | HubMed [Paper6]
  7. Susanna KA, Mironczuk AM, Smits WK, Hamoen LW, and Kuipers OP. A single, specific thymine mutation in the ComK-binding site severely decreases binding and transcription activation by the competence transcription factor ComK of Bacillus subtilis. J Bacteriol. 2007 Jul;189(13):4718-28. DOI:10.1128/JB.00281-07 | PubMed ID:17468244 | HubMed [Paper7]
  8. Veening JW, Smits WK, Hamoen LW, and Kuipers OP. Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media. J Appl Microbiol. 2006 Sep;101(3):531-41. DOI:10.1111/j.1365-2672.2006.02911.x | PubMed ID:16907804 | HubMed [Paper8]
  9. Smits WK, Kuipers OP, and Veening JW. Phenotypic variation in bacteria: the role of feedback regulation. Nat Rev Microbiol. 2006 Apr;4(4):259-71. DOI:10.1038/nrmicro1381 | PubMed ID:16541134 | HubMed [Paper9]
  10. Smits WK, Dubois JY, Bron S, van Dijl JM, and Kuipers OP. Tricksy business: transcriptome analysis reveals the involvement of thioredoxin A in redox homeostasis, oxidative stress, sulfur metabolism, and cellular differentiation in Bacillus subtilis. J Bacteriol. 2005 Jun;187(12):3921-30. DOI:10.1128/JB.187.12.3921-3930.2005 | PubMed ID:15937154 | HubMed [Paper10]
  11. Smits WK, Eschevins CC, Susanna KA, Bron S, Kuipers OP, and Hamoen LW. Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development. Mol Microbiol. 2005 May;56(3):604-14. DOI:10.1111/j.1365-2958.2005.04488.x | PubMed ID:15819618 | HubMed [Paper11]
  12. Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, Kuipers OP, and Dubnau D. The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. J Bacteriol. 2005 Mar;187(6):2010-9. DOI:10.1128/JB.187.6.2010-2019.2005 | PubMed ID:15743949 | HubMed [Paper12]
  13. Veening JW, Smits WK, Hamoen LW, Jongbloed JD, and Kuipers OP. Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis. Appl Environ Microbiol. 2004 Nov;70(11):6809-15. DOI:10.1128/AEM.70.11.6809-6815.2004 | PubMed ID:15528548 | HubMed [Paper13]
  14. Baerends RJ, Smits WK, de Jong A, Hamoen LW, Kok J, and Kuipers OP. Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data. Genome Biol. 2004;5(5):R37. DOI:10.1186/gb-2004-5-5-r37 | PubMed ID:15128451 | HubMed [Paper14]
  15. Hamoen LW, Smits WK, de Jong A, Holsappel S, and Kuipers OP. Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach. Nucleic Acids Res. 2002 Dec 15;30(24):5517-28. PubMed ID:12490720 | HubMed [Paper15]

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  16. ISBN:9789036730310 [Book1]
  17. ISBN:9783540749202 [Book2]

All Medline abstracts: PubMed | HubMed


(under construction)

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