User:Wayne G. Shreffler

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Contact Info

Wayne G. Shreffler

Wayne G. Shreffler, MD, PhD

Mount Sinai School of Medicine; box 1198

Immunology Institute/ Division of Allergy and Immunology

One Gustave L Levy Place

New York, NY 10029



Immunology Institute

Academia.edu

Mount Sinai


Education

  • 1998, MD, New York University
  • 1997, PhD, New York University
  • 1996, MS, New York University
  • 1991, BS, University of Washington

Research interests

  1. Mechanisms of Allergenicity
  2. Immune Tolerance and Food Allergy
  3. Mechanisms of Immediate Hypersensitivity and its Regulation

Publications

PubMed Link

Selected Research Articles

  1. Wanich N, Nowak-Wegrzyn A, Sampson HA, and Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr;123(4):789-94.e20. DOI:10.1016/j.jaci.2008.12.1128 | PubMed ID:19348919 | HubMed [Paper1]
  2. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, and Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan;123(1):43-52.e7. DOI:10.1016/j.jaci.2008.09.051 | PubMed ID:19130927 | HubMed [Paper2]
  3. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, and Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar;121(3):737-743.e10. DOI:10.1016/j.jaci.2007.11.039 | PubMed ID:18234310 | HubMed [Paper3]
  4. Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, and Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15;177(6):3677-85. PubMed ID:16951327 | HubMed [Paper4]
  5. Shreffler WG, Lencer DA, Bardina L, and Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct;116(4):893-9. DOI:10.1016/j.jaci.2005.06.033 | PubMed ID:16210066 | HubMed [Paper5]
  6. Shreffler WG, Beyer K, Chu TH, Burks AW, and Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr;113(4):776-82. DOI:10.1016/j.jaci.2003.12.588 | PubMed ID:15100687 | HubMed [Paper6]
All Medline abstracts: PubMed | HubMed

Selected Review Articles

  1. Lin J, Bardina L, and Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009;524:259-72. DOI:10.1007/978-1-59745-450-6_19 | PubMed ID:19377951 | HubMed [Paper1]
  2. Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb;123(2):352-3. DOI:10.1016/j.jaci.2008.12.1119 | PubMed ID:19203659 | HubMed [Paper2]
  3. Moloney M and Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov;101(5):544-9. DOI:10.1016/S1081-1206(10)60295-5 | PubMed ID:19055210 | HubMed [Paper3]
  4. Berin MC and Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun;121(6):1311-20; quiz 1321-2. DOI:10.1016/j.jaci.2008.04.023 | PubMed ID:18539190 | HubMed [Paper4]
  5. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):226-33. DOI:10.1097/01.all.0000225165.83144.2f | PubMed ID:16670519 | HubMed [Paper5]
All Medline abstracts: PubMed | HubMed

Useful links