User:Ulrich Schlecht

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I am a new member of OpenWetWare!

Contact Info

Ulrich Schlecht (an artistic interpretation)
  • Ulrich Schlecht, PhD
  • Stanford University
  • Stanford Genome Technology Center
  • 855 S California Ave
  • Palo Alto, CA-94304, United States
  • Email me through OpenWetWare

I work in the Davis lab at Stanford University. I learned about OpenWetWare from co-worker.


  • 2007-2011, Postdoctoral Fellow, Stanford University
  • 2006, PhD, University of Basel, Switzerland
  • 2002, Diploma, University of Stuttgart, Germany

Research interests

  1. Assay development for drug discovery
  2. Condition-dependent changes in protein-protein interactions


  1. St Onge R, Schlecht U, Scharfe C, and Evangelista M. Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism. Molecules. 2012 Nov 5;17(11):13098-115. DOI:10.3390/molecules171113098 | PubMed ID:23128089 | HubMed [Paper1]
  2. Wu M, Zheng M, Zhang W, Suresh S, Schlecht U, Fitch WL, Aronova S, Baumann S, Davis R, St Onge R, Dill DL, and Peltz G. Identification of drug targets by chemogenomic and metabolomic profiling in yeast. Pharmacogenet Genomics. 2012 Dec;22(12):877-86. DOI:10.1097/FPC.0b013e32835aa888 | PubMed ID:23076370 | HubMed [Paper2]
  3. Schlecht U, St Onge RP, Walther T, François JM, and Davis RW. Cationic amphiphilic drugs are potent inhibitors of yeast sporulation. PLoS One. 2012;7(8):e42853. DOI:10.1371/journal.pone.0042853 | PubMed ID:22905177 | HubMed [Paper3]
  4. Schlecht U, Miranda M, Suresh S, Davis RW, and St Onge RP. Multiplex assay for condition-dependent changes in protein-protein interactions. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9213-8. DOI:10.1073/pnas.1204952109 | PubMed ID:22615397 | HubMed [Paper4]
  5. Oh J, Fung E, Schlecht U, Davis RW, Giaever G, St Onge RP, Deutschbauer A, and Nislow C. Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection. PLoS Pathog. 2010 Oct 7;6(10):e1001140. DOI:10.1371/journal.ppat.1001140 | PubMed ID:20949076 | HubMed [Paper5]
  6. Varela E, Schlecht U, Moina A, Fackenthal JD, Washburn BK, Niederhauser-Wiederkehr C, Tsai-Pflugfelder M, Primig M, Gasser SM, and Esposito RE. Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast. Genetics. 2010 Jul;185(3):841-54. DOI:10.1534/genetics.109.113746 | PubMed ID:20407133 | HubMed [Paper6]
  7. Schlecht U, Erb I, Demougin P, Robine N, Borde V, van Nimwegen E, Nicolas A, and Primig M. Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast. Mol Biol Cell. 2008 May;19(5):2193-207. DOI:10.1091/mbc.E07-12-1242 | PubMed ID:18305101 | HubMed [Paper7]
  8. Cottet S, Michaut L, Boisset G, Schlecht U, Gehring W, and Schorderet DF. Biological characterization of gene response in Rpe65-/- mouse model of Leber's congenital amaurosis during progression of the disease. FASEB J. 2006 Oct;20(12):2036-49. DOI:10.1096/fj.06-6211com | PubMed ID:17012256 | HubMed [Paper8]
  9. Wiederkehr C, Basavaraj R, Sarrauste de Menthière C, Koch R, Schlecht U, Hermida L, Masdoua B, Ishii R, Cassen V, Yamamoto M, Lane C, Cherry M, Lamb N, and Primig M. Database model and specification of GermOnline Release 2.0, a cross-species community annotation knowledgebase on germ cell differentiation. Bioinformatics. 2004 Mar 22;20(5):808-11. DOI:10.1093/bioinformatics/bth030 | PubMed ID:14751982 | HubMed [Paper9]
  10. Schlecht U, Demougin P, Koch R, Hermida L, Wiederkehr C, Descombes P, Pineau C, Jégou B, and Primig M. Expression profiling of mammalian male meiosis and gametogenesis identifies novel candidate genes for roles in the regulation of fertility. Mol Biol Cell. 2004 Mar;15(3):1031-43. DOI:10.1091/mbc.E03-10-0762 | PubMed ID:14718556 | HubMed [Paper10]
  11. Wiederkehr C, Basavaraj R, Sarrauste de Menthière C, Hermida L, Koch R, Schlecht U, Amon A, Brachat S, Breitenbach M, Briza P, Caburet S, Cherry M, Davis R, Deutschbauer A, Dickinson HG, Dumitrescu T, Fellous M, Goldman A, Grootegoed JA, Hawley R, Ishii R, Jégou B, Kaufman RJ, Klein F, Lamb N, Maro B, Nasmyth K, Nicolas A, Orr-Weaver T, Philippsen P, Pineau C, Rabitsch KP, Reinke V, Roest H, Saunders W, Schröder M, Schedl T, Siep M, Villeneuve A, Wolgemuth DJ, Yamamoto M, Zickler D, Esposito RE, and Primig M. GermOnline, a cross-species community knowledgebase on germ cell differentiation. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D560-7. DOI:10.1093/nar/gkh055 | PubMed ID:14681481 | HubMed [Paper11]
  12. Primig M, Wiederkehr C, Basavaraj R, Sarrauste de Menthière C, Hermida L, Koch R, Schlecht U, Dickinson HG, Fellous M, Grootegoed JA, Hawley RS, Jégou B, Maro B, Nicolas A, Orr-Weaver T, Schedl T, Villeneuve A, Wolgemuth DJ, Yamamoto M, Zickler D, Lamb N, and Esposito RE. GermOnline, a new cross-species community annotation database on germ-line development and gametogenesis. Nat Genet. 2003 Dec;35(4):291-2. DOI:10.1038/ng1203-291 | PubMed ID:14647278 | HubMed [Paper12]
  13. Schlecht U and Primig M. Mining meiosis and gametogenesis with DNA microarrays. Reproduction. 2003 Apr;125(4):447-56. PubMed ID:12683916 | HubMed [Paper13]
  14. Weingärtner M, Siegmund D, Schlecht U, Fotin-Mleczek M, Scheurich P, and Wajant H. Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis. J Biol Chem. 2002 Sep 20;277(38):34853-9. DOI:10.1074/jbc.M205149200 | PubMed ID:12105203 | HubMed [Paper14]
  15. Schlecht U, Nomura Y, Bachmann T, and Karube I. Reversible surface thiol immobilization of carboxyl group containing haptens to a BIAcore biosensor chip enabling repeated usage of a single sensor surface. Bioconjug Chem. 2002 Mar-Apr;13(2):188-93. PubMed ID:11906254 | HubMed [Paper15]
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