User:Timothy L. Foley

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Contact Info

Tim Foley (an intoxicated interpretation)

Timothy L. Foley
NIH Chemical Genomics Center/ NIH Center for Translational Therapeutics
9800 Medical Center Drive
Bldg B, rm 1022
Bethesda, MD 20850

I just finished my graduate work in the Burkart Lab at University of California, San Diego; and am currently relocating to Washington, D.C. to start a postdoctoral position at the NIH Chemical Genomics Center

  • 2010, PhD, Chemistry, University of California, San Diego
  • 2006, MS, Chemistry, University of California, San Diego
  • 2004, BS, Cell Biology & Biochemistry, University of California, San Diego

Research interests

  • Therapeutically active small molecules from Nature
  • Enzyme structure and function
  • Metabolic pathway engineering
  • New antibiotics
  • Neglected diseases
  • Chemical genetics
  • Chemical probe development
  • Bacterial cell wall assembly

Publications

  1. Yu WL, Guizzunti G, Foley TL, Burkart MD, and La Clair JJ. An optimized immunoaffinity fluorescent method for natural product target elucidation. J Nat Prod. 2010 Oct 22;73(10):1659-66. DOI:10.1021/np100371k | PubMed ID:20836515 | HubMed [mAb35]
  2. Foley TL, Yasgar A, Garcia CJ, Jadhav A, Simeonov A, and Burkart MD. Preparation of FRET reporters to support chemical probe development. Org Biomol Chem. 2010 Oct 21;8(20):4601-6. DOI:10.1039/c0ob00322k | PubMed ID:20725690 | HubMed [DyeChem]
  3. Yasgar A, Foley TL, Jadhav A, Inglese J, Burkart MD, and Simeonov A. A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase. Mol Biosyst. 2010 Feb;6(2):365-75. DOI:10.1039/b913291k | PubMed ID:20094656 | HubMed [LOPAC]
  4. Foley TL, Young BS, and Burkart MD. Phosphopantetheinyl transferase inhibition and secondary metabolism. FEBS J. 2009 Dec;276(23):7134-45. DOI:10.1111/j.1742-4658.2009.07425.x | PubMed ID:19895578 | HubMed [anthanilate]
  5. Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel JP, DiPasquale AG, Rheingold AL, and La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov;72(11):1980-7. DOI:10.1021/np9002838 | PubMed ID:19842686 | HubMed [laetirubin]
  6. Meier JL, Niessen S, Hoover HS, Foley TL, Cravatt BF, and Burkart MD. An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. ACS Chem Biol. 2009 Nov 20;4(11):948-57. DOI:10.1021/cb9002128 | PubMed ID:19785476 | HubMed [OASIS]
  7. Foley TL and Burkart MD. A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Anal Biochem. 2009 Nov 1;394(1):39-47. DOI:10.1016/j.ab.2009.06.037 | PubMed ID:19573516 | HubMed [Assay_01]
  8. Meier JL, Barrows-Yano T, Foley TL, Wike CL, and Burkart MD. The unusual macrocycle forming thioesterase of mycolactone. Mol Biosyst. 2008 Jun;4(6):663-71. DOI:10.1039/b801397g | PubMed ID:18493665 | HubMed [MLTE]
  9. Foley TL and Burkart MD. Site-specific protein modification: advances and applications. Curr Opin Chem Biol. 2007 Feb;11(1):12-9. DOI:10.1016/j.cbpa.2006.11.036 | PubMed ID:17189712 | HubMed [Review]
  10. La Clair JJ, Foley TL, Schegg TR, Regan CM, and Burkart MD. Manipulation of carrier proteins in antibiotic biosynthesis. Chem Biol. 2004 Feb;11(2):195-201. DOI:10.1016/j.chembiol.2004.02.010 | PubMed ID:15123281 | HubMed [ChemBiol]
All Medline abstracts: PubMed | HubMed

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