Difference between revisions of "User:Sunny Sharma"

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==Contact Info==
 
==Contact Info==
  
*Sunny Sharma
+
*Sunny Sharma, PhD
*Institute of Molecular Biosciences, Max-von-Laue Strasse-9, Campus Riedberg, Goethe University
+
*
*Frankfurt am Main, Hesse, Germany.
 
 
*[[Special:Emailuser/Sunny Sharma|Email me through OpenWetWare]]
 
*[[Special:Emailuser/Sunny Sharma|Email me through OpenWetWare]]
 
I am graduate student in [[Entian´s Lab]] at Goethe University, Frankfurt am Main.
 
  
 
==Education==
 
==Education==
 
<!--Include info about your educational background-->
 
<!--Include info about your educational background-->
* PhD student at Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany [http://www.uni-frankfurt.de/fb/fb15/english/institute/inst-3-mol-biowiss/]
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* Research Fellow at MGH Cancer Center– Harvard Medical School
 +
* Research Associate at Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany [http://www.uni-frankfurt.de/fb/fb15/english/institute/inst-3-mol-biowiss/]
 +
* 2014, PhD (Biology), Goethe University, Frankfurt am Main, Germany [http://www.uni-frankfurt.de/fb/fb15/english/institute/inst-3-mol-biowiss/]
 
* 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [http://department.gndu.ac.in/department/molecular.asp]
 
* 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [http://department.gndu.ac.in/department/molecular.asp]
 
*2005, BS, Bangalore University, Bangalore, India [http://www.bangaloreuniversity.ac.in/]
 
*2005, BS, Bangalore University, Bangalore, India [http://www.bangaloreuniversity.ac.in/]
  
 
== Awards ==
 
== Awards ==
DAAD (Deutsche Akademische Austauschdienst) PhD scholarship [https://www.daad.de/de/index.html]
 
  
CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship [http://www.cef-mc.de/index.php?id=2]
+
EMBO (European Molecular Biology Organisation) Long Term Fellowship. (2014-2016)[http://www.embo.org/]
  
ICMR (Indian Council of Medical Research) Junior Research Fellowship [http://www.cef-mc.de/index.php?id=2]
+
DAAD (Deutsche Akademische Austauschdienst) PhD scholarship (2010 - 2014) [https://www.daad.de/de/index.html]
 +
 
 +
CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship (2009 - 2010) [http://www.cef-mc.de/index.php?id=2]
 +
 
 +
ICMR (Indian Council of Medical Research) Junior Research Fellowship (2009 - 2010) [http://www.icmr.nic.in/]
  
 
==Research interests==
 
==Research interests==
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# Ribosome Biogenesis
 
# Ribosome Biogenesis
 
# RNA modifications
 
# RNA modifications
 +
# Developmental Biology
 
#Immunology
 
#Immunology
 
# Gerontology
 
# Gerontology
  
 +
==Publications==
 +
17) Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.[https://www.nature.com/articles/s41598-017-09734-9]
 +
 +
 +
16) Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.[http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006804]
 +
 +
 +
15) Mapping of Complete Set of Ribose and Base Modifications of Yeast rRNA by RP-HPLC and Mung Bean Nuclease Assay.[http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168873]
 +
 +
 +
14) Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function.[http://www.tandfonline.com/doi/full/10.1080/15476286.2016.1259781]
 +
 +
 +
13) Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. [http://nar.oxfordjournals.org/content/early/2016/04/15/nar.gkw244.abstract]
 +
 +
 +
12)‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification.[http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004%2815%2900139-5]
 +
 +
 +
11) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.[http://nar.oxfordjournals.org/content/early/2015/09/13/nar.gkv895.full]
 +
 +
 +
10) Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.[http://nar.oxfordjournals.org/content/early/2015/02/03/nar.gkv075.full]
 +
 +
 +
9) Identification of a new ribose methylation in the 18S rRNA of S. cerevisiae.[http://nar.oxfordjournals.org/content/early/2015/02/03/nar.gkv058.abstract]
 +
 +
 +
8) Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.[http://www.ncbi.nlm.nih.gov/pubmed/25635753]
 +
 +
 +
7) Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.[http://www.ncbi.nlm.nih.gov/pubmed/25129236]
 +
 +
 +
6) Partial methylation at Am100 in 18S rRNA of baker´s yeast shows ribosome heterogeneity on the level of eukaryotic rRNA modification. Plos One [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089640]
 +
 +
 +
5) Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.[http://nar.oxfordjournals.org/content/early/2013/12/11/nar.gkt1281.full]
 +
 +
 +
4) Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.[http://www.ncbi.nlm.nih.gov/pubmed/23913415]
 +
 +
 +
3) Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.[http://www.ncbi.nlm.nih.gov/pubmed/23558746]
 +
 +
 +
2) Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.[http://www.ncbi.nlm.nih.gov/pubmed/23180764]
  
==Publications==
 
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
 
<biblio>
 
# Paper1 pmid=23180764 
 
  
#Paper2 pmid=20819262
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1) Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.[http://www.ncbi.nlm.nih.gov/pubmed/20819262]
  
 +
==Conferences/ Workshops==
  
</biblio>
+
# Plenary talk at 10th Ribosome Synthesis meeting 19th-25th August, Brussels.[http://events.embo.org/15-ribosomes/]
 +
# Seminar at RNA club, 16th October 2013 [http://www.rnaclub.de/img/RNACLUB_20131016.pdf ]
 +
# Plenary talk at Yeast Meeting, Frankfurt 2013 [http://www.yeast-2013.org/faces/index]
 +
# Poster presentation at 18th Annual RNA meeting of the RNA society, Davos, Switzerland  [http://www.rnasociety.org/conferences/rna-2013/]
 +
# Seminar at RNA club, 26th September 2012 [http://www.rnaclub.de/img/RNACLUB_20120926.pdf]
 +
# Poster presentation at 9th International Conference on Ribosome Synthesis, Banff, Canada [http://www.rochester.edu/College/BIO/ribosyn2012/]
  
 
==Useful links==
 
==Useful links==
 +
*http://www.muk.uni-frankfurt.de/53895688/033?
 
*http://www.yeastgenome.org/
 
*http://www.yeastgenome.org/
 +
*http://www.rnaclub.de
 
*http://people.biochem.umass.edu/fournierlab/3dmodmap/main.php
 
*http://people.biochem.umass.edu/fournierlab/3dmodmap/main.php
 
*http://modomics.genesilico.pl/
 
*http://modomics.genesilico.pl/

Latest revision as of 18:32, 20 September 2017

Contact Info

Education

  • Research Fellow at MGH Cancer Center– Harvard Medical School
  • Research Associate at Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany [1]
  • 2014, PhD (Biology), Goethe University, Frankfurt am Main, Germany [2]
  • 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [3]
  • 2005, BS, Bangalore University, Bangalore, India [4]

Awards

EMBO (European Molecular Biology Organisation) Long Term Fellowship. (2014-2016)[5]

DAAD (Deutsche Akademische Austauschdienst) PhD scholarship (2010 - 2014) [6]

CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship (2009 - 2010) [7]

ICMR (Indian Council of Medical Research) Junior Research Fellowship (2009 - 2010) [8]

Research interests

  1. Ribosome Biogenesis
  2. RNA modifications
  3. Developmental Biology
  4. Immunology
  5. Gerontology

Publications

17) Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.[9]


16) Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.[10]


15) Mapping of Complete Set of Ribose and Base Modifications of Yeast rRNA by RP-HPLC and Mung Bean Nuclease Assay.[11]


14) Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function.[12]


13) Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. [13]


12)‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification.[14]


11) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.[15]


10) Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.[16]


9) Identification of a new ribose methylation in the 18S rRNA of S. cerevisiae.[17]


8) Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.[18]


7) Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.[19]


6) Partial methylation at Am100 in 18S rRNA of baker´s yeast shows ribosome heterogeneity on the level of eukaryotic rRNA modification. Plos One [20]


5) Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.[21]


4) Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.[22]


3) Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.[23]


2) Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.[24]


1) Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.[25]

Conferences/ Workshops

  1. Plenary talk at 10th Ribosome Synthesis meeting 19th-25th August, Brussels.[26]
  2. Seminar at RNA club, 16th October 2013 [27]
  3. Plenary talk at Yeast Meeting, Frankfurt 2013 [28]
  4. Poster presentation at 18th Annual RNA meeting of the RNA society, Davos, Switzerland [29]
  5. Seminar at RNA club, 26th September 2012 [30]
  6. Poster presentation at 9th International Conference on Ribosome Synthesis, Banff, Canada [31]

Useful links