User:Shannon K. Alford
I am a new member of OpenWetWare!
Biological Engineering 20.109 Instructor & Research Scientist
- Office: Bldg 56-389
- Lab: Blgd 56-378
- Office Phone: 617-258-9488
- Email: skalford AT mit DOT edu
My Research interests
Aberrant cell migration is a hallmark of several invasive diseases, such as metastatic cancer and systemic autoimmune disorders. I am particularly interested in the regulation of cell motility and the underlying intracellular signaling processes as modulated by interaction with the cytoskeleton. My current research combines biochemical, cell biological and systems biological engineering approaches to elucidate the intracellular signaling mechanism underlying increased breast cancer metastasis due to expression of an invasion-specific protein, MenaINV.
- Goldbeter A and Koshland DE Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4.
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56.
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