User:Scott W. Nelson

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Contact Info

Scott W. Nelson (an artistic interpretation)
  • Scott W. Nelson, Assistant Professor
  • Iowa State University
  • 4112 Molecular Biology Building
  • Iowa State University
  • Ames, IA 50010.
  • Email me through OpenWetWare

Education

  • 2002, PhD, Biochemistry, Iowa State University
  • 1997, BS, Biotechnology, North Dakota State University

Research interests

  1. DNA replication and repair
  2. allostery
  3. protein dynamics

Publications

  1. Spiering MM, Nelson SW, and Benkovic SJ. Repetitive lagging strand DNA synthesis by the bacteriophage T4 replisome. Mol Biosyst. 2008 Nov;4(11):1070-4. DOI:10.1039/b812163j | PubMed ID:18931782 | HubMed [Paper1]
  2. Nelson SW, Kumar R, and Benkovic SJ. RNA primer handoff in bacteriophage T4 DNA replication: the role of single-stranded DNA-binding protein and polymerase accessory proteins. J Biol Chem. 2008 Aug 15;283(33):22838-46. DOI:10.1074/jbc.M802762200 | PubMed ID:18511422 | HubMed [Paper2]
  3. Nelson SW and Benkovic SJ. The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. J Biol Chem. 2007 Jan 5;282(1):407-16. DOI:10.1074/jbc.M608153200 | PubMed ID:17092935 | HubMed [Paper3]
  4. Yang J, Nelson SW, and Benkovic SJ. The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. Mol Cell. 2006 Jan 20;21(2):153-64. DOI:10.1016/j.molcel.2005.11.029 | PubMed ID:16427006 | HubMed [Paper4]
  5. Yang J, Nelson SW, and Benkovic SJ. The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. Mol Cell. 2006 Jan 20;21(2):153-64. DOI:10.1016/j.molcel.2005.11.029 | PubMed ID:16427006 | HubMed [Paper5]
  6. Nelson SW, Binkowski DJ, Honzatko RB, and Fromm HJ. Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Biochemistry. 2005 Jan 18;44(2):766-74. DOI:10.1021/bi048191w | PubMed ID:15641804 | HubMed [Paper6]
  7. Nelson SW, Honzatko RB, and Fromm HJ. Origin of cooperativity in the activation of fructose-1,6-bisphosphatase by Mg2+. J Biol Chem. 2004 Apr 30;279(18):18481-7. DOI:10.1074/jbc.M308811200 | PubMed ID:14978036 | HubMed [Paper7]
  8. Choe JY, Nelson SW, Arienti KL, Axe FU, Collins TL, Jones TK, Kimmich RD, Newman MJ, Norvell K, Ripka WC, Romano SJ, Short KM, Slee DH, Fromm HJ, and Honzatko RB. Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors. J Biol Chem. 2003 Dec 19;278(51):51176-83. DOI:10.1074/jbc.M308396200 | PubMed ID:14530289 | HubMed [Paper8]
  9. Choe JY, Nelson SW, Fromm HJ, and Honzatko RB. Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase. J Biol Chem. 2003 May 2;278(18):16008-14. DOI:10.1074/jbc.M212394200 | PubMed ID:12595529 | HubMed [Paper9]
  10. Nelson SW, Honzatko RB, and Fromm HJ. Hybrid tetramers of porcine liver fructose-1,6-bisphosphatase reveal multiple pathways of allosteric inhibition. J Biol Chem. 2002 May 3;277(18):15539-45. DOI:10.1074/jbc.M112304200 | PubMed ID:11854289 | HubMed [Paper10]
  11. Wen J, Nelson SW, Honzatko RB, Fromm HJ, and Petrich JW. Environment of tryptophan 57 in porcine fructose-1,6-bisphosphatase studied by time-resolved fluorescence and site-directed mutagenesis. Photochem Photobiol. 2001 Nov;74(5):679-85. PubMed ID:11723795 | HubMed [Paper11]
  12. Nelson SW, Honzatko RB, and Fromm HJ. Spontaneous subunit exchange in porcine liver fructose-1,6-bisphosphatase. FEBS Lett. 2001 Mar 16;492(3):254-8. PubMed ID:11257504 | HubMed [Paper12]
  13. Nelson SW, Kurbanov FT, Honzatko RB, and Fromm HJ. The N-terminal segment of recombinant porcine fructose-1,6-bisphosphatase participates in the allosteric regulation of catalysis. J Biol Chem. 2001 Mar 2;276(9):6119-24. DOI:10.1074/jbc.M009485200 | PubMed ID:11096109 | HubMed [Paper13]
  14. Nelson SW, Iancu CV, Choe JY, Honzatko RB, and Fromm HJ. Tryptophan fluorescence reveals the conformational state of a dynamic loop in recombinant porcine fructose-1,6-bisphosphatase. Biochemistry. 2000 Sep 12;39(36):11100-6. PubMed ID:10998248 | HubMed [Paper14]
  15. Nelson SW, Choe JY, Honzatko RB, and Fromm HJ. Mutations in the hinge of a dynamic loop broadly influence functional properties of fructose-1,6-bisphosphatase. J Biol Chem. 2000 Sep 29;275(39):29986-92. DOI:10.1074/jbc.M000473200 | PubMed ID:10896931 | HubMed [Paper15]
All Medline abstracts: PubMed | HubMed

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