User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory

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Project Description/Abstract

Notes

Outline

  1. Application
  2. Grand Challenges
  3. Start-up experiments
  4. Review Articles

Project List

Conceptual questions

  • In the abstract level, how could we live with imperfect efficiency? No matter writing mechanism we choose in the end, the fraction of cells whose genome is actually rewritten will likely to be significantly less than a hundred percent.
  • What are the common/ different challenges between writing memory to DNA versus gene therapy/ transgenic?

TO DO List

  • reading
  • Write up the detail structure and mechanism of integrase
  • Take a look at how virus hijack a host and take control of host machinery (i.e. look at Covert's large

scale viral-bacterial models). May be the first step for engineering a cell it to modify the virus to control the cell the way we want.

  • discuss HT-in vivo protein evolution project with Jennifer, James, Quake's pp
  • Maybe I should start focusing on specific memory encoding problem..like counting the number of cell cycle.

..many signaling protein rise and fall in each cell cycle, so as the copy number of genome..we might be able to make use of them.

Recent changes

26 September 2017

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(Upload log). .

[Pauline Wonnenberg‎; Sayyed Ourmazd Mohseni‎; Blake A. McCal‎ (2×); Wesley Groves‎ (4×)]

     

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. . Wesley Groves (talk | contribs) uploaded File:Mean bar graph w standard dev.png

     

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. . Sayyed Ourmazd Mohseni (talk | contribs) uploaded a new version of File:Heart Rate.png

     

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. . Wesley Groves (talk | contribs) uploaded File:Scatter with r value correct.png

     

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. . Wesley Groves (talk | contribs) uploaded File:Scatter plot with r.png

     

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. . Wesley Groves (talk | contribs) uploaded File:Screen Shot 2017-09-26 at 12.26.36 PM.png

     

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. . Blake A. McCal (talk | contribs) uploaded File:G3TempScatter.PNG

     

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. . Blake A. McCal (talk | contribs) uploaded File:G3TempBar.PNG

     

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. . Pauline Wonnenberg (talk | contribs) uploaded File:09-06 Titrations Table.png

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Hoatlin:CONJ606.PMCB How the class works‎‎ (10 changes | history) . . (+708). . [Maureen E. Hoatlin‎ (10×)]

     

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Li Lab:Publications‎‎ (6 changes | history) . . (+756). . [Wei Li Bcm‎ (6×)]

     

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(cur | prev) . . (0). . Wei Li Bcm (talk | contribs) (Peer Reviewed Publications)

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Li Lab‎‎ (2 changes | history) . . (+278). . [Wei Li Bcm‎ (2×)]

     

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     11:40  User:Pauline Wonnenberg/Notebook/CHEM 471 Fall 2017/2017/09/06‎ (diff | hist) . . (+123). . Pauline Wonnenberg (talk | contribs) (Entry title)