User:Michael Fischbach

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Michael Fischbach (an artistic interpretation)
  • Michael Fischbach
  • Massachusetts General Hospital
  • Department of Molecular Biology
  • Massachusetts General Hospital
  • Simches Research Center
  • 185 Cambridge Street
  • Boston, MA 02114
  • Email me through OpenWetWare


  • 2007, PhD, Harvard University
  • 2003, AB, Harvard College


  1. Wieland Brown LC, Acker MG, Clardy J, Walsh CT, and Fischbach MA. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2549-53. DOI:10.1073/pnas.0900008106 | PubMed ID:19196969 | HubMed [Paper31]
  2. Walsh CT and Fischbach MA. Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1689-90. DOI:10.1073/pnas.0813405106 | PubMed ID:19193851 | HubMed [Paper30]
  3. López D, Fischbach MA, Chu F, Losick R, and Kolter R. Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):280-5. DOI:10.1073/pnas.0810940106 | PubMed ID:19114652 | HubMed [Paper29]
  4. Sattely ES, Fischbach MA, and Walsh CT. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep. 2008 Aug;25(4):757-93. DOI:10.1039/b801747f | PubMed ID:18663394 | HubMed [Paper28]
  5. Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, Clarke K, Cronin A, Davis P, Goodhead I, Holroyd N, Jagels K, Lord A, Moule S, Mungall K, Norbertczak H, Quail MA, Rabbinowitsch E, Walker D, White B, Whitehead S, Small PL, Brosch R, Ramakrishnan L, Fischbach MA, Parkhill J, and Cole ST. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res. 2008 May;18(5):729-41. DOI:10.1101/gr.075069.107 | PubMed ID:18403782 | HubMed [Paper27]
  6. Fischbach MA, Walsh CT, and Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4601-8. DOI:10.1073/pnas.0709132105 | PubMed ID:18216259 | HubMed [Paper26]
  7. Walsh CT and Fischbach MA. Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics. Angew Chem Int Ed Engl. 2008;47(31):5700-2. DOI:10.1002/anie.200801801 | PubMed ID:18576462 | HubMed [Paper25]
  8. Nolan EM, Fischbach MA, Koglin A, and Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. J Am Chem Soc. 2007 Nov 21;129(46):14336-47. DOI:10.1021/ja074650f | PubMed ID:17973380 | HubMed [Paper24]
  9. Fischbach MA, Lai JR, Roche ED, Walsh CT, and Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11951-6. DOI:10.1073/pnas.0705348104 | PubMed ID:17620609 | HubMed [Paper23]
  10. Fischbach MA and Clardy J. One pathway, many products. Nat Chem Biol. 2007 Jul;3(7):353-5. DOI:10.1038/nchembio0707-353 | PubMed ID:17576415 | HubMed [Paper22]
  11. Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, and Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1506-9. DOI:10.1073/pnas.0610503104 | PubMed ID:17234808 | HubMed [Paper21]
  12. Straight PD, Fischbach MA, Walsh CT, Rudner DZ, and Kolter R. A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):305-10. DOI:10.1073/pnas.0609073103 | PubMed ID:17190806 | HubMed [Paper20]
  13. Clardy J, Fischbach MA, and Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol. 2006 Dec;24(12):1541-50. DOI:10.1038/nbt1266 | PubMed ID:17160060 | HubMed [Paper19]
  14. Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, and Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16502-7. DOI:10.1073/pnas.0604636103 | PubMed ID:17060628 | HubMed [Paper18]
  15. Fischbach MA and Walsh CT. Biochemistry. Directing biosynthesis. Science. 2006 Oct 27;314(5799):603-5. DOI:10.1126/science.1132692 | PubMed ID:17068249 | HubMed [Paper17]
  16. Lai JR, Fischbach MA, Liu DR, and Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. J Am Chem Soc. 2006 Aug 30;128(34):11002-3. DOI:10.1021/ja063238h | PubMed ID:16925399 | HubMed [Paper16]
  17. Larsen NA, Lin H, Wei R, Fischbach MA, and Walsh CT. Structural characterization of enterobactin hydrolase IroE. Biochemistry. 2006 Aug 29;45(34):10184-90. DOI:10.1021/bi060950i | PubMed ID:16922493 | HubMed [Paper15]
  18. Jin M, Fischbach MA, and Clardy J. A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc. 2006 Aug 23;128(33):10660-1. DOI:10.1021/ja063194c | PubMed ID:16910643 | HubMed [Paper14]
  19. Fischbach MA and Walsh CT. Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev. 2006 Aug;106(8):3468-96. DOI:10.1021/cr0503097 | PubMed ID:16895337 | HubMed [Paper13]
  20. Lin H, Fischbach MA, Gatto GJ Jr, Liu DR, and Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. J Am Chem Soc. 2006 Jul 26;128(29):9324-5. DOI:10.1021/ja063236x | PubMed ID:16848455 | HubMed [Paper12]
  21. Sharma SV, Fischbach MA, Haber DA, and Settleman J. "Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res. 2006 Jul 15;12(14 Pt 2):4392s-4395s. DOI:10.1158/1078-0432.CCR-06-0096 | PubMed ID:16857816 | HubMed [Paper11]
  22. Lai JR, Fischbach MA, Liu DR, and Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5314-9. DOI:10.1073/pnas.0601038103 | PubMed ID:16567620 | HubMed [Paper10]
  23. Fischbach MA, Lin H, Liu DR, and Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol. 2006 Mar;2(3):132-8. DOI:10.1038/nchembio771 | PubMed ID:16485005 | HubMed [Paper9]
  24. Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, and Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. ACS Chem Biol. 2006 Feb 17;1(1):29-32. DOI:10.1021/cb0500034 | PubMed ID:17163637 | HubMed [Paper8]
  25. Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, and Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 2006 Feb 14;45(6):1537-46. DOI:10.1021/bi052333k | PubMed ID:16460000 | HubMed [Paper7]
  26. Garstecki P, J Fuerstman M, Fischbach MA, Sia SK, and Whitesides GM. Mixing with bubbles: a practical technology for use with portable microfluidic devices. Lab Chip. 2006 Feb;6(2):207-12. DOI:10.1039/b510843h | PubMed ID:16450029 | HubMed [Paper6]
  27. Fischbach MA and Settleman J. Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase. Methods Enzymol. 2006;407:33-45. DOI:10.1016/S0076-6879(05)07004-7 | PubMed ID:16757312 | HubMed [Paper5]
  28. Lin H, Fischbach MA, Liu DR, and Walsh CT. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc. 2005 Aug 10;127(31):11075-84. DOI:10.1021/ja0522027 | PubMed ID:16076215 | HubMed [Paper4]
  29. Fischbach MA, Lin H, Liu DR, and Walsh CT. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):571-6. DOI:10.1073/pnas.0408463102 | PubMed ID:15598734 | HubMed [Paper3]
  30. Wolfe DB, Conroy RS, Garstecki P, Mayers BT, Fischbach MA, Paul KE, Prentiss M, and Whitesides GM. Dynamic control of liquid-core/liquid-cladding optical waveguides. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12434-8. DOI:10.1073/pnas.0404423101 | PubMed ID:15314232 | HubMed [Paper2]
  31. Fischbach MA and Settleman J. Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase. Cancer Res. 2003 Jul 15;63(14):4089-94. PubMed ID:12874011 | HubMed [Paper1]

All Medline abstracts: PubMed | HubMed

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