Difference between revisions of "User:Megan N McClean"

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==Contact Info==
 
==Contact Info==
[[Image:Horseshoe.jpg|thumb|right|Megan N McClean (an artistic interpretation)]]
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[[Image:Megan1.jpg|150px|right|Megan N. McClean]]
  
 
*Megan N McClean
 
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*[[Special:Emailuser/Megan N McClean|Email me through OpenWetWare]]
 
*[[Special:Emailuser/Megan N McClean|Email me through OpenWetWare]]
  
I am a Lewis-Sigler fellow at Princeton.
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I am a Lewis-Sigler fellow at Princeton University.
  
 
==Education==
 
==Education==
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==Research interests==
 
==Research interests==
 
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# Cellular decision-making processes
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The McClean lab studies the design principles underlying the signal processing capabilities of biological networks. Cellular signaling networks transmit information about environmental stimuli to the interior of the cell, where successive cellular responses take place. How these networks process their input dictates cellular behavior and fitness. We are interested in how signaling pathways and transcriptional networks are designed to appropriately filter input and set thresholds so that cells respond optimally to changes in their environment. We are also interested in understanding how these networks are adapted and fine-tuned throughout development (short timescale) or evolution (long timescale). The lab takes an experimental approach combining microfluidics with microscopy to monitor the responses of signaling pathways to complex stimuli.
# In vivo kinetics of signaling cascades
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Please check out my Princeton webpage here: [http://www.princeton.edu/genomics/mcclean/ McClean Lab at Princeton ]
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Check out our lab webpage on openwetware here: [http://openwetware.org/wiki/McClean McClean Lab on Openwetware]
  
 
==Publications==
 
==Publications==
 
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#Paper pmid=18480263
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#Paper1 pmid=18480263
 
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#Paper2 pmid=17259986
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#Paper3 pmid=19177008  
 
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#Paper4 pmid=19116106
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#Paper pmid=19116106
 
 
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==Useful links==
 
==Useful links==
 
*[[OpenWetWare:Welcome|Introductory tutorial]]
 
*[[OpenWetWare:Welcome|Introductory tutorial]]
 
*[[Help|OpenWetWare help pages]]
 
*[[Help|OpenWetWare help pages]]

Revision as of 06:35, 16 February 2012

Contact Info

Megan N. McClean


I am a Lewis-Sigler fellow at Princeton University.

Education

  • 2009, PhD, Harvard
  • 2005, MS, Harvard
  • 2003, BA, University of California at Berkeley

Research interests

The McClean lab studies the design principles underlying the signal processing capabilities of biological networks. Cellular signaling networks transmit information about environmental stimuli to the interior of the cell, where successive cellular responses take place. How these networks process their input dictates cellular behavior and fitness. We are interested in how signaling pathways and transcriptional networks are designed to appropriately filter input and set thresholds so that cells respond optimally to changes in their environment. We are also interested in understanding how these networks are adapted and fine-tuned throughout development (short timescale) or evolution (long timescale). The lab takes an experimental approach combining microfluidics with microscopy to monitor the responses of signaling pathways to complex stimuli.

Please check out my Princeton webpage here: McClean Lab at Princeton

Check out our lab webpage on openwetware here: McClean Lab on Openwetware

Publications

  1. Hersen P, McClean MN, Mahadevan L, and Ramanathan S. Signal processing by the HOG MAP kinase pathway. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7165-70. DOI:10.1073/pnas.0710770105 | PubMed ID:18480263 | HubMed [Paper1]
  2. McClean MN, Mody A, Broach JR, and Ramanathan S. Cross-talk and decision making in MAP kinase pathways. Nat Genet. 2007 Mar;39(3):409-14. DOI:10.1038/ng1957 | PubMed ID:17259986 | HubMed [Paper2]
  3. McClean MN, Hersen P, and Ramanathan S. In vivo measurement of signaling cascade dynamics. Cell Cycle. 2009 Feb 1;8(3):373-6. DOI:10.4161/cc.8.3.7450 | PubMed ID:19177008 | HubMed [Paper3]
  4. Hersen P, McClean M, and Ramanathan S. [Dynamic analysis of cell signalling: the example of the Saccharomyces cerevisiae osmotic response]. Med Sci (Paris). 2008 Dec;24(12):1020-2. DOI:10.1051/medsci/200824121020 | PubMed ID:19116106 | HubMed [Paper4]
All Medline abstracts: PubMed | HubMed

Useful links