Difference between revisions of "User:Jungwhan Kim"

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[[Image:cellcover.gif|frame|250px|right|''Cell Metabolism Cover Mar 2006'']]
[[Image:cellcover.gif|frame|250px|right|''Cell Metabolism Cover Mar 2006'']]
'''The role of stromal HIFs in the development of breast cancer'''

Revision as of 08:32, 11 August 2008




Jungwhan Kim, D.V.M., Ph.D.

Post-Doctoral Fellow (Randall Johnson Lab)

Division of Biological Sciences

University of California, San Diego (UCSD)

9500 Gilman Drive NSB 5325A, La Jolla, CA 92093

Lab Tel) 858-822-5832

Email: vetjayk@gmail.com

Current Research Interests

Cell Metabolism Cover Mar 2006

The role of stromal HIFs in the development of breast cancer

Previous Research Interests

Nature Reviews Cancer Cover Jan 2008

I have been studying the molecular mechanisms underlying oncogenic alterations of cellular metabolism by the c-Myc oncoprotein (Myc Target Gene Database). c-Myc heterodimerizes with Max to bind specific DNA sequences (CACGTG), termed E box and transactivates its target genes. Using phylogenetic footprinting and chromatin immunoprecipitation (ChIP) assays, I found that c-Myc overexpression activates genes encoding proteins involved in glycolysis and contributes to the Warburg effect or aerobic glycolysis, which is characteristic of essentially all solid tumors (Kim J. et.al. MCB, 2004). c-Myc-mediated aerobic glycolysis is further modulated by hypoixc tumor microenvironment. I demonstrated that in cancer, dysregulated c-Myc cooperates with HIF-1 to enhance glycolysis and angiogenesis (Kim J. et.al. MCB 2007.,Dang C. et. al. Nature Reviews Cancer 2008) I also have been studying metabolic reprogramming of cells in response to hypoxia. I found that hypoxic induction of pyruvate dehydrogenase kinase 1 (PDK1) actively suppresses mitochondrial functions, which results in preserving oxygen consumption and attenuating ROS production under hypoxic conditions (Kim J. et. al. Cell Metabolism, 2006).This metabolic shift confers optimization of efficient respiration of hypoxic cells, which contributes to tumor progression under hypoxic microenvironment. These studies lead to the concept that tumor bioenergetics derived from either cell autonomous oncogenic events or adaptive responses to hypoxic microenvironment could be an attractive target for the cancer therapeutics.


Professional Training

  • Researcher; 2000 Feb - 2000 Sep ; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea
  • Research Fellow; 2000 - 2002 ; University of Pennsylvania, School of Medicine, Dept. of Pathology & Lab Medicine (Supervisor; Ruth J. Muschel, M.D., Ph.D.)
  • Post-Doctoral Fellow; 2006 - 2007 ; Johns Hopkins University, School of Medicine, Maryland, USA. Dept. of Medicine (Supervisor; Chi V. Dang, M.D., Ph.D.)
  • Post-Doctoral Fellow; 2007 - 2008 ; University of California San Francisco, School of Medicine, California, USA
  • Post-Doctoral Fellow; 2008 - present ; University of California San Diego, Division of Biological Sciences, California, USA (Supervisor; Randall S. Johnson, Ph.D.)

Academic Awards

  • Achievement Award for the 1st rank in The Veterinary National Board Examination, Korea (2000)
  • Dean’s Award for Academic Achievement, summa cum laude, Kon-kuk University, School of Veterinary Medicine, Seoul, Korea (2000)
  • Howard Hughes Medical Institute (HHMI), Pre-Doctoral Fellowship (2003 - 2006)
  • Pathology Young Investigators’ day Award, Excellence in Basic Research, Dept. of Pathology, Johns Hopkins, School of Medicine (2004)
  • Keystone Symposia Scholarship, Metabolomics: From Bioenergetics to Apoptosis (2006)
  • Susan G. Komen Foundation Post-Doctoral Fellowship (2008)

Publications (Link to Full Text)

  1. Hosein Kouros-Mehr, Jung-whan Kim, Seth K. Bechis, and Zena Werb. GATA-3 and the Regulation of the Mammary Luminal Cell Fate. Current Opinion in Cell Biology 20:164-170 (2008)
  2. Chi V. Dang, Jung-whan Kim, Ping Gao, and Jason Yustein. The Interplay between MYC and HIF in Cancer. Nature Reviews Cancer 8:51-56 (2008)
  3. Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza and Chi V. Dang. HIF-1 and dysregulated c-Myc cooperatively induce VEGF and metabolic switches, HK2 and PDK1. Mol. Cell. Biol. 27:7381-7393 (2007)
  4. Jung-whan Kim, Ping Gao, and Chi V. Dnag. Effects of hypoxia on tumor metabolism. Cancer and Metastasis Reviews. 26:291-8 (2007)
  5. Ryo Fukuda, Huafeng Zhang, Jung-whan Kim, Larissa Shimoda, Chi V. Dang, and Gregg L. Semenza. HIF-1 regulates cytochrome oxidase subunit composition to optimize the efficiency of respiration of hypoxic cells. Cell 129:111-122 (2007)
  6. Jung-whan Kim, and Chi V. Dang. Cancer's molecular sweet tooth and the Warburg effect. Cancer Research 66:8927-8930 (2006)
  7. Jung-whan Kim, Irina Tchernyshyov, Gregg L. Semenza, and Chi V. Dang. HIF-1-mediated expression of PDK: a metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3:177-185 (2006)
  8. Kathryn O'Donnell, Duonan Yu, Karen I. Zeller, Jung-whan Kim, Frederick Racke, Andrei Thomas-Tikhonenko and Chi V. Dang. Transferrin Receptor 1 is a direct Myc target gene required for cell cycle progression, Mol. Cell. Biol. 26:2373-2386 (2006)
  9. Rong Mao, Xiaowen Wang, Edward L. Spitznagel Jr., Laurence P. Frelin, Jason C. Ting, Huashi Ding, Jung-whan Kim, Ingo Ruczinski, Thomas J. Downey, and Jonathan Pevsner. Role of Gene Expression in the Developing Human Down Syndrome Brain and Heart. Genome Biology, 6:R107 (2005)
  10. Jung-whan Kim, Lawrence B. Gardner and Chi V. Dang. Oncogenic Alterations of Metabolism and the Warburg Effect. Drug Discovery Today: Disease Mechanisms, 2:233-235 (2005)
  11. Feng Li, Diane Wonsey, Young Ko, Kathryn O'Donnell, Karen I. Zeller, Jung-whan Kim, Jason Yustein, Linda A. Lee and Chi V. Dang. Myc stimulates mitochondrial biogenesis and nuclear encoded mitochondrial genes, Mol. Cell. Biol. 25: 6225-6234 (2005)
  12. Jung-whan Kim and Chi V. Dang. Multifaceted Roles of Glycolytic Enzymes. Trends in Biochemical Sciences, 30:142-150 (2005)
  13. Seung-Hoon Lee, Jung-whan Kim, Sun-Hee Oh, Yong-Jin Kim, Seung-Bae Rho, Kyungsook Park, Kui-Lea Park and Je-ho Lee. IFN-gamma/IRF-1-induced p27 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Letters,579:1027-1033 (2005)
  14. Jung-whan Kim, Karen I. Zeller, Yunyue Wang, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O'Donnell, and Chi V. Dang. Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays. Mol. Cell. Biol. 24:5923-5936 (2004)
  15. Jung-whan Kim, Christopher W. Wong, Jeffery D. Goldsmith, C.Song, Weili Fu, Mary-Beth Allion, Meenhard Herlyn, Abu B. Al-Mehdi, and Ruth J. Muschel. Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Letters, 213:203-212 (2004)
  16. Seung-Hoon Lee, Jung-whan Kim, Yongsuk Cho, Sunhee Oh, Hanwoong Lee, Wei Zhang and Jeho Lee. Interferon Regulatory Factor 1 (IRF-1) Is a Mediator for Interferon-g-induced Attenuation of Telomerase Activity and Human Telomerase Reverse Transcriptase (hTERT) Expression. Oncogene,22:381-391 (2003)
  17. Seung-Hoon Lee, Wei Zhang, Jung-joo Choi, Yong-Suk Cho, Sun-Hee Lee, Jung-whan Kim, Limei Hu, Jie Xu, Jinsong Liu and Joho Lee. Overexpression of the Thymosin beta-10 Gene in Human Ovarian Cancer Cells Disrupts F-Actin Stress Fiber and Leads to Apoptosis. Oncogene,20:6700-6706 (2001)
  18. Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001)

Book Chapters

  1. Chi V. Dang, Ping Gao and Jung-whan Kim. The Warburg effect and tumor metabolism. Encyclopedia of CANCER In press