Difference between revisions of "User:Jon Sack"

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==Research interests==
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# Interest 1
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Jon Sack, Ph.D.
# Interest 2
 
# Interest 3
 
  
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===Research interests===
  
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In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.
  
==Education==
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===Education===
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* 2003 PhD, Stanford University, Department of Biological Sciences
 
* 1997, BA, Reed College, Major in Biochemistry
 
  
==Contact Info==
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Ph.D., Stanford University, Department of Biological Sciences
[[Image:OWWEmblem.png|thumb|right|Jon Sack (an artistic interpretation)]]
 
  
Institute for Design of Intelligent Drugs
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B.A., Reed College, Biochemistry
Protean Research
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941 Roble Ridge
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===Institutional Affiliation===
Palo Alto, California 94306
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650.384.5792 tel 
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Assistant Professor
650.716.5222 fax
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Department of Physiology & Membrane Biology
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School of Medicine
  
Department of Neurobiology, Physiology & Behavior
 
College of Biological Sciences
 
 
University of California
 
University of California
196 Briggs Hall
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4126 Tupper Hall
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One Shields Avenue
 
One Shields Avenue
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Davis, California 95616
 
Davis, California 95616
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530.752.4131 tel
 
530.752.4131 tel
530.754.6079 fax
 
 
jsack (at) ucdavid (dot) edu
 
  
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed -->
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530.752.5314 lab tel
  
==Useful links==
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530.752.5423 fax
*[[OpenWetWare:Welcome|Introductory tutorial]]
 
*[[Help|OpenWetWare help pages]]
 

Latest revision as of 20:36, 12 December 2012


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Sackshot.jpg

Jon Sack, Ph.D.

Research interests

In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.

Education

Ph.D., Stanford University, Department of Biological Sciences

B.A., Reed College, Biochemistry

Institutional Affiliation

Assistant Professor

Department of Physiology & Membrane Biology

School of Medicine

University of California

4126 Tupper Hall

One Shields Avenue

Davis, California 95616

530.752.4131 tel

530.752.5314 lab tel

530.752.5423 fax