Difference between revisions of "User:Jayajit Das"

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==Useful links==
 
==Useful links==
* Detailed CV: [[das_cv_jan_09_web.pdf]]
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* Detailed CV: [[Image:das_cv_jan_09_web.pdf]]

Revision as of 11:51, 23 January 2009

I am a new member of OpenWetWare!

Contact Info

Jayajit.jpg
  • Jayajit Das

Assistant Professor
Battelle Center for Mathematical Medicine
The Research Institute at Nationwide Children's Hospital
Biophysics Graduate Program and Department of Pediatrics
Ohio State University, Columbus, OH 43205

Email: das.70 @ osu.edu; jayajit.das @ nationwidechildrens.org ; jayajit @ gmail.com
Phone: 614-355-4526 (work)
Fax: 614-355-2728

Education and Professional Experience

  • 2005-2008 Postdoctoral Fellow, Massachusetts Institute of Technology
  • 2002-2005 Postdoctoral Fellow, University of California at Berkeley
  • 2000-2002 Postdoctoral Fellow, Virginia Institute of Polytechnic and State University
  • 2000 Ph.D. Physics, Raman Research Institute, Bangalore, India
  • 1996 M.Sc. Physics, Institute of Mathematical Sciences, Chennai (Madras) India
  • 1994 B.Sc. Physics, Presidency College, Kolkata(Calcutta), India

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

Selected Publications

  1. Jayajit Das, Mary Ho, Julie Zikherman, Christopher Govern, Ming Yang, Arthur Weiss, Arup K. Chakraborty and Jeroen Roose, Digital signaling and hystersis characterize ras activation in lymphocytes Cell, vol. 136, p. 337 (2009). [Paper1]
  2. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, and Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):528-33. DOI:10.1073/pnas.0805981105 | PubMed ID:19098101 | HubMed [Paper2]
  3. Cemerski S, Das J, Giurisato E, Markiewicz MA, Allen PM, Chakraborty AK, and Shaw AS. The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity. 2008 Sep 19;29(3):414-22. DOI:10.1016/j.immuni.2008.06.014 | PubMed ID:18760640 | HubMed [Paper3]
  4. Artyomov MN, Das J, Kardar M, and Chakraborty AK. Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18958-63. DOI:10.1073/pnas.0706110104 | PubMed ID:18025473 | HubMed [Paper4]
  5. Wylie DC, Das J, and Chakraborty AK. Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5533-8. DOI:10.1073/pnas.0611482104 | PubMed ID:17360359 | HubMed [Paper5]
  6. Cemerski S, Das J, Locasale J, Arnold P, Giurisato E, Markiewicz MA, Fremont D, Allen PM, Chakraborty AK, and Shaw AS. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity. 2007 Mar;26(3):345-55. DOI:10.1016/j.immuni.2007.01.013 | PubMed ID:17346997 | HubMed [Paper6]
All Medline abstracts: PubMed | HubMed

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