Difference between revisions of "User:Etienne Robillard/Notebook/Schiff base"

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=== Introduction to Schiff bases ===
Learning resources:
* Part 1: [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]
* Part 2: [http://www.chem.ucalgary.ca/courses/350/Carey5th/Ch21/ch21-4-3.html Micheal reaction]
=== Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes ===
* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
** pharmacological intermediates (N-substituted heterocyclics)
** Nucleophilic carbonyl addition
** PS: <font color="red">Yb(OTf)3</font> route to '''1,2,3,4-tetrahydroisoquinolines''' derivatives.
** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
=== Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase ===
* Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
* Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
* Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are [[User:Etienne_Robillard/Notebook/Phenylmethylamine|here]].
* Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.
=== Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :) ===
Student resources:
* [[User:Etienne_Robillard/Notebook/Phenylmethanamine|Phenylmethanamine]]
* [[Ethanamine]]
Teaching Topics:
* Troika acids
* Toxicity of cyanophosphate-derived cross-linker reagents exposure : Alcoholism like psychotic symptoms. Acute psychotic (visual..) hallucinations (Note: Long-term rehabilitation is often necessary.. :)
* Effects of cyanide on Yb(OTf)3 conformational polypeptide (1,2,3,4-tetrahydroisoquinolines) isomerisation ?
* Remote activation of <font color=purple>Gold</font> (Yb) nanoparticles ? hmm.. star trek style drug delivery :)
* <font color=purple style="background:#ddd">'''The [Ph]C=N double bond linkage may be a result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst. [1]</font> [[Image:500px-Diethyl cyanophosphate.svg.png|thumb|right|Example cyanophosphate-derived synthetic reagent. (PMID: 1818086, 15670935)]]
* Assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno= EC] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
* tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable mRNA polymerase repressor functions (LuxR) and AHL evidences in the design of <font color="red">Schiff base conjugated (6xHis tag) psychochemicals to induce (lazy) light-activated mRNA transcription and metabolism</font>. -[[User:Etienne_Robillard|ER]]
* Also Verify this lazy RNA polymerase function: <math>2ATP+CO^2->Ph^2CO<=>2N+2ROH</math> -[[User:Etienne_Robillard|ER]]
* carbanion = cyanide anion
* 6his-tag = a C6 hexanoyl based heterocyclic carbanion -- N-substituted oxazoles derivatives (imine)
=== The Monsanto connection: Troika acids; novel cyanophosphonate compounds as N-substituted (alkyl) drug carrier (pharmacochemical intermediates) ===
* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: <font color=purple>for binding ca2+/mg2+ ions to a recombinant "fusion" protein...</font>)
* Chuck: If you want to spray civilians without impunity, be sure to include a cyanoethyl moeity...
* Oracle: Are you kidding? Once upon a time cyanide was at the basis of the Zyklon-b pellet...
* Oracle: Hence, the magnitude and scale of civilians exposure to the new compound is probably most effective today.
* Chuck: For next time, how about a ban of spraying civilians with pharmacochemical intermediates ?
* Oracle: Go ask Obama!
* Chuck: LOL
* Oracle: Go ask Monsanto! When should it become natural to breath air ? Is this a luxury reserved for an elite golf club ?
* Chuck: And Is this the reason I'm being emprisonned ?
* Chuck: Because I refuse to happily breath such things while the majority of the breed have no clue what the heck a troika acid is composed of?
=== References ===
# [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Imine (Schiff base) formation] - Highly recommended primer documentation on Schiff bases
# http://www.wikigenes.org/e/chem/e/7046.html - 1,2,3,4-tetrahydroisoquinoline. (Note: A anti-malarial pharmaceutical compound comparable to mefloquine. Compound may be implicated in 4-trans like enantiomer substitution (conformational) leading to '''acute psychotic hallucinations'''. See: [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [http://chemistry.umeche.maine.edu/CHY251/cyclo6.html this document] for a more concise explanation.) 
<font color=purple style="background:#ddd">Synthesis and conformational rearrangement of benzoxadiazole derivatives with disubstituted (-N=Ph[2]C) isocyanate ligands [phosphoramido-cyanidate]</font>
# DOI:10.1021/ja00132a045 [ISOCYANIDES1]
# DOI:10.1002/anie.197205301 [ISOCYANIDES2] (<font color=purple style="background: #ddd">Hofmann/Ugi route to PS, Wilmslow</font>)
# http://www.ncbi.nlm.nih.gov/pubmed/16953613
# http://www.nizkor.org/ftp.cgi/camps/auschwitz/cyanide/cyanide.001
# http://www.state.gov/www/global/arms/treaties/cwc/cwcann.html - In Schedule 1A(2), Schedule 2B(6)
Tyrosine kinase (GPCR) signaling with Troika acids (disubstituted Chair Conformer Cyclohexane Ring system):
# ​[http://www.plantphysiol.org/content/148/3/1668 Protein Tyrosine Kinases and Protein Tyrosine Phosphatases Are Involved in Abscisic Acid-Dependent Processes in Arabidopsis Seeds and Suspension Cells]
# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156371/ Small Ubiquitin-Like Modifier Modulates Abscisic Acid Signaling in Arabidopsis]
# cis/trans stuff (Look for section "Conformational Structures of Disubstituted Cyclohexanes", 4th row from the top) : http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/sterism2.htm
=== Did you know? ===
'"Attitude is a little thing that makes a big difference." - Winston Churchill

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