User:Etienne Robillard/Notebook/Phenethylamine

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2-phenethylamine (PEA) - a monoamine neurotransmitter ligand. Compare this with "2-cyclohexylethylamine" and "N-substituted arylcyclohexylamines". [Keywords: Ugi route to Wilmslow]


  • Etienne Robillard 20:45, 20 February 2013 (EST) There you have it. Be good scientists now and let the world know how irate this chemical equation is as a tool to mentally subvert unaware populations with orthogonal ketamine adducts to medicate the youths without their consents and knowledge about the pernicious and invasive functions of their wireless microwave reactors to polymerize alkane drugs in situ!

Agent Yankee Dodge: The making of synthetic Ketamine adducts

Excerpt from

"The dropping of one carbon from the phenethylamine chain gives a benzyl amine, basically an inactive nucleus. Two families deserve mention, however. The phencylidine area, phenylcyclohexylpiperidine or PCP, is represented by a number of benzyl amines. Ketamine is also a benzyl amine. These are all analgesics and anesthetics with central properties far removed from the stimulant area, and are not really part of this book. There is a benzyl amine that is a pure stimulant, which has been closely compared to amphetamine in its action This is benzylpiperazine, a base that is active in the 20 to 100 milligram range, but which has an acceptability similar to amphetamine. If this is a valid stimulant, I think that much magic might be found in and around compounds such as (1) the MDMA analogue, N-(3,4-methylenedioxybenzyl)piperazine (or its N-methyl-counterpart N-(3,4-methylenedioxybenzyl)-N'-methylpiperazine) or (2) the DOM analogue, 2,5-dimethoxy-4-methylbenzylpiperazine. The benzyl amine that results by the relocation of the amine group of MDA from the beta-carbon atom to the alpha-carbon atom is known, and is active. It, and its N-methyl homologue, are described and discussed in the commentary under MDA. Dropping another carbon atom gives a yet shorter chain (no carbons at all!) and this is to be found in the phenylpiperazine analogue 3-trifluoromethylphenylpiperazine. I have been told that this base is an active hallucinogen as the dihydrobromide salt at 50 milligrams sublingually, or at 15 milligrams intravenously in man. The corresponding 3-chloro analogue at 20 to 40 milligrams orally in man or at 8 milligrams intravenously, led to panic attacks in some 10% of the experimental subjects, but not to any observed psychedelic or stimulant responses."

See also

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