User:Tkadm30/Notebook/Paliperidone/2013/10/10: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
Line 4: Line 4:
# Investigate CYP2D6  
# Investigate CYP2D6  
# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/2013/06/21|PLP biosynthesis]]...)
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|PLP biosynthesis from 9-oh risperidone]]...)
# Study (Mg+ATP) hydrolisis further  
# Study (Mg+ATP) hydrolisis further  
## include notes about AU-bound metal catalysts, OPH ''''hydrolase''' (AuNP hydrosols)
## include notes about AU-bound metal catalysts, OPH ''''hydrolase''' (AuNP hydrosols)

Revision as of 12:46, 10 October 2013

9-OH (risperidone) degradation scrachpad

  • Todo:
  1. Investigate CYP2D6
  2. Establish Role of Aldehyde oxidase in paliperidone metabolite degradation
  3. Confirm degradation of metabolite vs no inhibitor (as for PLP biosynthesis from 9-oh risperidone...)
  4. Study (Mg+ATP) hydrolisis further
    1. include notes about AU-bound metal catalysts, OPH 'hydrolase (AuNP hydrosols)