Difference between revisions of "User:Etienne Robillard/Notebook/Paliperidone/2013/10/10"

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(9-OH (risperidone) degradation scrachpad)
(9-OH (risperidone) degradation scrachpad)
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# Investigate CYP2D6  
 
# Investigate CYP2D6  
 
# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
 
# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/2013/06/21|PLP biosynthesis]]...)
+
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|PLP biosynthesis from 9-oh risperidone]]...)
 
# Study (Mg+ATP) hydrolisis further  
 
# Study (Mg+ATP) hydrolisis further  
 
## include notes about AU-bound metal catalysts, OPH ''''hydrolase''' (AuNP hydrosols)
 
## include notes about AU-bound metal catalysts, OPH ''''hydrolase''' (AuNP hydrosols)

Revision as of 11:46, 10 October 2013

9-OH (risperidone) degradation scrachpad

  • Todo:
  1. Investigate CYP2D6
  2. Establish Role of Aldehyde oxidase in paliperidone metabolite degradation
  3. Confirm degradation of metabolite vs no inhibitor (as for PLP biosynthesis from 9-oh risperidone...)
  4. Study (Mg+ATP) hydrolisis further
    1. include notes about AU-bound metal catalysts, OPH 'hydrolase (AuNP hydrosols)