Difference between revisions of "User:Etienne Robillard/Notebook/Paliperidone/2013/10/10"

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(9-OH (risperidone) degradation scrachpad)
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# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
 
# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
 
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|PLP biosynthesis from 9-oh risperidone]]...)
 
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|PLP biosynthesis from 9-oh risperidone]]...)
# Study (Mg+ATP) hydrolisis further  
+
# Study (Mg+ATP) hydrolysis further  
 
## include notes about AU-bound metal catalysts, OPH '''hydrolase''' (AuNP hydrosols)
 
## include notes about AU-bound metal catalysts, OPH '''hydrolase''' (AuNP hydrosols)
 +
## Take notes about serine <font color=blue>racemase</font color> ([http://www.uniprot.org/uniprot/Q9GZT4 Uniprot]. Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
 +
 
==See also==
 
==See also==
 
[[User:Etienne_Robillard/Notebook/OPH|OPH Notebook]]
 
[[User:Etienne_Robillard/Notebook/OPH|OPH Notebook]]

Revision as of 11:55, 17 October 2013

9-OH (risperidone) degradation scrachpad

  • Todo:
  1. Investigate CYP2D6
  2. Establish Role of Aldehyde oxidase in paliperidone metabolite degradation
  3. Confirm degradation of metabolite vs no inhibitor (as for PLP biosynthesis from 9-oh risperidone...)
  4. Study (Mg+ATP) hydrolysis further
    1. include notes about AU-bound metal catalysts, OPH hydrolase (AuNP hydrosols)
    2. Take notes about serine racemase (Uniprot. Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")

See also

OPH Notebook