Difference between revisions of "User:Etienne Robillard/Notebook/Paliperidone/2013/06/21"

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(Design philosophy)
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So you have been forced by a foolish human-android to acknowledge the insanity of this so-called society ? Don't worry, bud, we'll work something out
as always :)
The purposes and aims of this experiment are two folds: First, we want you to avoid being mentally harmed while being forced to take antipsychotics drugs. Second, we want
you to find a way to functionalize the degradation of the psychoactive compound into a non-psychoactive, and safe [http://jb.oxfordjournals.org/content/112/1/139.short racemase].
===Design philosophy===
* broad spectrum specificity : The degradation of the optically-active racemate must accept many substrates. (ie: pines and dones)
* Fast, safe, and side-effects free bioremoval of the metabolite.
===Starting Material===
* paliperidone: an atypical antipsychotic derived from Risperidone. see [[User:Etienne_Robillard/Notebook/Risperidone|Risperidone]].
* clozanpine: another atypical antipsychotic
* citric acid : refer to "Citric acid cycle"
* racemate:
* racemase:
* racemization:
* ketoacidosis:
* reagent:
* methylation:
* glucoronide:
* amide:
* ester:
* transaminase:
* transaldimination:
* ec NAD-specific isocitrate dehydrogenase (an enzyme): http://www.kegg.jp/dbget-bin/www_bget?ec:
** pathway (Citrate cycle): http://www.kegg.jp/kegg-bin/show_pathway?ec00020+
# [http://dmd.aspetjournals.org/content/36/4/769.full Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans]
# [http://en.wikipedia.org/wiki/Beta-glucuronidase Wikipedia page on Beta-glucuronidase] (ec
===Did you know?===
The secret of education lies in respecting the pupil. - Ralph Waldo Emerson

Latest revision as of 04:48, 17 March 2015

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