Notes about OPH (Organo-Phosphate Hydrolase), an enzyme found in H. sapiens.
Use as voltage-gated, metal-bound electrolyte/proton conductor in cyclic imide additions (Maleimide)
- cyclic imide hydrolase (Maleimide) : http://www.kegg.jp/dbget-bin/www_bget?ec:220.127.116.11
- pathway (nicotinamide metabolism): http://www.kegg.jp/kegg-bin/show_pathway?map00760+C01596
- ATP-dependent hydrolase ?
- nicotinamide (NAD-specific) neurotoxic agent ?
- keywords: NADPH+, AuNP, ATP (hydrolysis), cyanophosphine
French Press 18.104.22.168 (123aa)
NKAGARREGSCGKPIGEDYLIEAFDDDGNMLERGGSGELCISSPTVMKGYLNDTEATEKT FLDYDGKRWLKTGDLGYVDKDGFIFILQRLKRIIKVSGVPVFPAEIERLVNTLKDVDECC AVGIEHKLKGKVIKLYVKSSAEP
Enzyme name is acyl-coA synthase.
doi: 10.1016/j.abb.2005.08.012, 10.1002/0471264180.or025.02
oph: A organo-phosphate (P-O) hydroxyl bound to a ketone or aldehyde. Synthetic intermediate and precursor to organo-phosphate agents known as AChE inhibitors. Reaction is catalyzed by the Organo-Phosphate Hydrolase enzyme, thus a (Mg)ATP-dependent ligase. See related DOIs above.
EC 22.214.171.124 (DFPase) http://www.genome.jp/dbget-bin/www_bget?ec:126.96.36.199
keywords: functionalized diphosphine, chim trills, DFP, Paraoxon
Reaction type: oxidative desulfuration (BioCyc)
BBC x GFP
- A sort of patented EGFP (chromophore) used as organo-phosphate dye (read dimer?).
- Used for detection of Sarin (GB) gas et al.
Unknown. The risks and effects of using succinic acid as calcium channel blocker may need further study.
- Turning a protein kinase on or off from a single allosteric site via disulfide trapping
- Ogawa J, Soong CL, Honda M, and Shimizu S. Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides. Eur J Biochem. 1997 Jan 15;243(1-2):322-7.
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