Difference between revisions of "User:Etienne Robillard/Notebook/DFP"

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== Overview ==
Notes about OPH (Organo-Phosphate Hydrolase), an enzyme
found in H. sapiens.
==Use as voltage-gated, metal-bound electrolyte/proton conductor in cyclic imide additions (Maleimide) ==
* cyclic imide hydrolase (Maleimide) : http://www.kegg.jp/dbget-bin/www_bget?ec:
* pathway (nicotinamide metabolism): http://www.kegg.jp/kegg-bin/show_pathway?map00760+C01596
* ATP-dependent hydrolase ?
* nicotinamide (NAD-specific) '''neurotoxic''' agent ? 
* keywords: NADPH+, AuNP, ATP (hydrolysis), cyanophosphine
===French Press (123aa)===
Enzyme name is acyl-coA synthase.
Pathway: http://www.kegg.jp/kegg-bin/show_pathway?T30165_04920+179507
[http://prosite.expasy.org/PS50001 Matrix]
doi: 10.1016/j.abb.2005.08.012, 10.1002/0471264180.or025.02
oph: A organo-phosphate (P-O) hydroxyl bound to a ketone or aldehyde. Synthetic intermediate and precursor to organo-phosphate agents known as [http://www.uniprot.org/uniprot/P22303 AChE] inhibitors. Reaction is catalyzed by the Organo-Phosphate Hydrolase enzyme, thus a (Mg)ATP-dependent ligase. See related DOIs above.
dfp (Isoflurophate): http://www.drugbank.ca/drugs/DB00677, [http://en.wikipedia.org/wiki/Isoflurophate Wikipedia]
EC  (DFPase) http://www.genome.jp/dbget-bin/www_bget?ec:
EC (Parathion hydrolase) http://www.uniprot.org/uniprot/P0A433, http://www.drugbank.ca/drugs/DB02138
[http://www.hmdb.ca/metabolites/HMDB13035 HMDB]
keywords: functionalized diphosphine, chim trills, DFP, Paraoxon
Reaction type: <font color=blue>oxidative desulfuration</font color> ([http://biocyc.org/META/NEW-IMAGE?type=COMPOUND&object=PARAOXON BioCyc])
Related: [http://www.uniprot.org/uniprot/O15530 3-phosphoinositide-dependent protein kinase 1], [http://www.uniprot.org/uniprot/Q00005 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform]
[http://www.jbc.org/content/283/3/1480.full Regulation of 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) by Src Involves Tyrosine Phosphorylation of PDK1 and Src Homology 2 Domain Binding]
=== BBC x GFP ===
* A sort of patented EGFP (chromophore) used as organo-phosphate dye (read dimer?).
* Used for detection of Sarin (GB) gas et al.
* Notes:
# What is a chromophore?
# More info on '''EGFP''' may be found [[GFP|here]].
# US Patent:
== Safety ==
Unknown. The risks and effects of using succinic acid as calcium channel blocker may need further
# http://www.ccrc.uga.edu/~rcarlson/bcmb3100/Chap27.pdf
# http://www.ebi.ac.uk/interpro/entry/IPR000980
# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076885/ Turning a protein kinase on or off from a single allosteric site via disulfide trapping]
#imidase pmid=9030755
==Did you know?==
Love isn't something you find. Love is something that finds you.
- Loretta Young

Latest revision as of 17:31, 20 July 2015

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