User:Etienne Robillard/Notebook/Methylphenidate/2013/06/15

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MW induced active methylene enolate synthesis

Lazy, untested protocol for remotely-triggered blue cheese (amphetamine-induced) psychosis.

What we know so far: The bliss of ignorance is deeper in the region of tyranny.

For remote activation of active formamide (methyl-ene) enolate reduction using electromagnetic heat of branched alcohols: see Acetaldehyde: A sort of (aryl conjugated) ethanolamine but this is controversial. :)

Chim trills at a glance: The reality of science is mathematically founded.

  • Reaction: Claisen-type Condensation (Michael addition) (confirm)
  • Chemical (Reagent): 2 (Dudley reagent/PMB), DMSO or DMF (confirm)
  • Phases: 1 (confirm)
  • Chemical (solvent): Benzylamine-like cyclohexane (Heterocyclics; NHC) (confirm)
  • Catalyst: Isonitrile (0.01 probability/confirm)
    • Why: reaction must occur with weak (neutral) base and in presence of a branched alcohol (benzaldehyde?) or toluene
  • Note 1: A reductive alkylation with a ortho phenyl ester (triethyl orthoformate?) (confirm)
  • Note 2: This probably indicate (p=0.01) the presence of a synthetic reagent to catalyze the isonitrile base into a compound identified as a active methylene enolate or more specifically methylphenidate hcl, a potent amphetamine-based dopamine inhibitor and GABA antagonist.
  • Related reactions: Ugi reaction, Dieckmann Condensation, Suzuki coupling (Pictet Spengler)
  • Starting materials: benzaldehyde (7c?), benzoyl acid (Chuck), trichloroisocyanuric acid (HCl?), THF
  • Related compounds: Arylcyclohexylamines, Methylphenidate (Ritalin), 1,2,3,4-tetrahydroisoquinoline (mefloquine), benzylamine (benzoxadiazole), Agent Buzz (15), 30C6HSL
  • Target receptors: NMDA1R (antagonist), S1PR4 (confirm), GABA, Dopamine, Serotonin, MAPK, EGFR
  • Primary phenotype: Alzheimer/Dementia (confirm)
  • Secondary phenotypes: Alcoholism, Parkinson, Breast Cancer
  • Probable method of one-pot/multi-step synthesis: Microwave-activated RF synthesis (Fmoc/carboxilic deprotection)
  • Reaction type: Organic synthesis

See also