User:Etienne Robillard/Notebook/Methylphenidate

From OpenWetWare
Jump to: navigation, search

The Acetoacetic Ester Condensation (Claisen Condensation...)

United States Patent 8283472 (note the cyanide mention at the top of the page...)

FRIEDEL-CRAFT acylation:

4-methylimidazole (4-Mel) -> 4-acylaminopyridine derivative: US7998971

Construction of optically active (4-trans) methylphenidate hcl derivatives !

GSK-3: glycogen synthase kinase 3 (inhibitor)

Never give up, never surrender

Cycloalkane -> Schiff base -> benzylamine protected enantiomer (ie: methylphenidate...)

Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate: a glycine-activated neural GABA antagonist

  • 130605:
    • doi: 10.1073/pnas.1005399107
    • until the 5th of july is over, you may want to review the Shikimate pathway :)
    • lovely:
    • Science reality ?
  • 130606:
    • Chuck:LOL really
    • Chuck: F...
    • Oracle: Dude, dont talk EVER to proper and finely educated ladies this way...
    • Oracle: There must exist a proper way to address the detention of peaceful civilian using non-violence...
    • Chuck: They must be thinking i'm a f<CENSORED> schizophreniac now.
    • Oracle: Yes. All the time. That not very interesting. Why are you asking all the times the same thing over and over again?
    • Chuck: They made plans to put me in a detention camp and test on me lethal drugs and lithium for 3 years.
    • Chuck: I don't like that. :(
    • Oracle: Insanity is dangerous.
    • Chuck: Especially when the purpose of this detention is to make me a chemical blue cheese. I love my sanity and my sweet kush. I don't want to be a fucking guinea pig for their human experiments with sulfonamides and shit.
    • Oracle: Bastards. Don't let them make you a fucking lunatic. Be independent.
    • Chuck: maybe worth trying some LSD next time. :)
    • Oracle: mush ?
    • Chuck: i love putting my Mushrooms in a soup! yay! :)

related documentation (possibly outdated)