User:Etienne Robillard/Notebook/Methylphenidate

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Revision as of 18:25, 5 July 2013 by Etienne Robillard (talk | contribs) (Have a happy 5th of july :))
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The Acetoacetic Ester Condensation (Claisen Condensation...)

United States Patent 8283472 (note the cyanide mention at the top of the page...)

FRIEDEL-CRAFT acylation:

4-methylimidazole (4-Mel) -> 4-acylaminopyridine derivative: US7998971

Construction of optically active (4-trans) methylphenidate hcl derivatives !

GSK-3: glycogen synthase kinase 3 (inhibitor)

Never give up, never surrender

Cycloalkane -> Schiff base -> benzylamine protected enantiomer (ie: methylphenidate...)

Microwave (RF) activated N-benzylformamide catalysis of 1,2-methylphenidate

  • 130605:
    • doi: 10.1073/pnas.1005399107
    • until the 5th of july is over, you may want to review the Shikimate pathway :)