Difference between revisions of "User:Etienne Robillard/Notebook/Methylphenidate"

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Revision as of 15:10, 6 July 2013


The Acetoacetic Ester Condensation (Claisen Condensation...)

United States Patent 8283472

http://en.wikipedia.org/wiki/Triethyl_orthoformate (note the cyanide mention at the top of the page...)

FRIEDEL-CRAFT acylation: http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch12/ch12-7.html

4-methylimidazole (4-Mel) -> 4-acylaminopyridine derivative: US7998971

Construction of optically active (4-trans) methylphenidate hcl derivatives ! http://www.seattlepi.com/news/article/Group-finds-carcinogen-in-Pepsi-outside-Calif-4644602.php

GSK-3: glycogen synthase kinase 3 (inhibitor)

Never give up, never surrender

Cycloalkane -> Schiff base -> benzylamine protected enantiomer (ie: methylphenidate...)

Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate

  • 130605:
    • doi: 10.1073/pnas.1005399107
    • until the 5th of july is over, you may want to review the Shikimate pathway :)
    • lovely:
    • Science reality ?

related documentation (possibly outdated)