Difference between revisions of "User:Etienne Robillard/Notebook/Methylphenidate"

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(Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate: a glycine-activated neural GABA antagonist)
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Revision as of 08:40, 8 July 2013


The Acetoacetic Ester Condensation (Claisen Condensation...)

United States Patent 8283472

http://en.wikipedia.org/wiki/Triethyl_orthoformate (note the cyanide mention at the top of the page...)

FRIEDEL-CRAFT acylation: http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch12/ch12-7.html

4-methylimidazole (4-Mel) -> 4-acylaminopyridine derivative: US7998971

Construction of optically active (4-trans) methylphenidate hcl derivatives ! http://www.seattlepi.com/news/article/Group-finds-carcinogen-in-Pepsi-outside-Calif-4644602.php

GSK-3: glycogen synthase kinase 3 (inhibitor)

Never give up, never surrender

Cycloalkane -> Schiff base -> benzylamine protected enantiomer (ie: methylphenidate...)

Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate: a glycine-activated neural GABA antagonist

  • 130605:
    • doi: 10.1073/pnas.1005399107
    • until the 5th of july is over, you may want to review the Shikimate pathway :)
    • lovely:
    • Science reality ?
  • 130606:
    • Chuck:LOL really
    • Chuck: F...
    • Oracle: Dude, dont talk EVER to proper and finely educated ladies this way...
    • Oracle: There must exist a proper way to address the detention of peaceful civilian using non-violence...
    • Chuck: They must be thinking i'm a f<CENSORED> schizophreniac now.
    • Oracle: Yes. All the time. That not very interesting. Why are you asking all the times the same thing over and over again?
    • Chuck: They made plans to put me in a detention camp and test on me lethal drugs and lithium for 3 years.
    • Chuck: I don't like that. :(
    • Oracle: Insanity is dangerous.
    • Chuck: Especially when the purpose of this detention is to make me a chemical blue cheese. I love my sanity and my sweet kush. I don't want to be a fucking guinea pig for their human experiments with sulfonamides and shit.
    • Oracle: Bastards. Don't let them make you a fucking lunatic. Be independent.
    • Chuck: maybe worth trying some LSD next time. :)
    • Oracle: mush ?
    • Chuck: i love putting my Mushrooms in a soup! yay! :)

related documentation (possibly outdated)