Difference between revisions of "User:Etienne Robillard/Notebook/GABA"

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To read later:
* [http://www.ncbi.nlm.nih.gov/pubmed/17928584 GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.]
* [http://www.ncbi.nlm.nih.gov/pubmed/18063801 Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase.]
** Original article is [http://www.schizophreniaforum.org/pap/annotation.asp?powID=114042 here].
* "GABA and Glycine" by Steven M. Paul (2000): http://www.acnp.org/g4/gn401000008/default.htm
=== Various Notes ===
* IFP: [http://www.openwetware.org/wiki/Image:Fluid_flow_mechanotransduction_pathways_mediated_by_primary_cilia_schematic.png Interstitial Fluid Pressure] - Ie the flow capacity for a "neuronal circuit" to mediate Ca2+ electric signals into Axons and Synapses.
**  Keywords: [http://www.openwetware.org/wiki/Flow_Calibration Flow Calibration], IFP, Flow Cytometry, GFP (Green Fluorescence Protein), Calcium signaling (Pathway), NMDAR, CREB1, ...
* striatal neuron: a fast-spiking interneuron located inside the striatum (part of the frontal cortex)
** Parvalbulmin (PV): http://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=5816 (chromosome 22)
** ATXN3: http://www.kegg.jp/dbget-bin/www_bget?hsa:4287 ([http://omim.org/entry/607047 OMIM])
** iPSC: "Induced Pluripotent Stem Cell"  (doi: 10.1016/S0896-6273(00)81068-5)
* pCREB1 protein binding factors:
** Estrogen signaling pathway (Check around '''GABAergic synapse''': <font color="red">How many CREB1 inducer <u>genes</u> can you identify?</font>): http://www.genome.jp/kegg-bin/show_pathway?ko04915+K05870
** Alcoholism (Note the direction of GABA and NMDAR induced interneurons): http://www.genome.jp/kegg-bin/show_pathway?ko05034+K05870
=== GlyT1 notes ===
* Chloride-dependent glycine transporter 1 (GlyT1): http://www.uniprot.org/uniprot/P48067
** Patent is [http://www.google.com/patents/US20060276655 here].
** [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023951/ Glycine Transport Inhibitors for the Treatment of Schizophrenia] (Free PMC) (2010)
** [http://www.schizophreniaoptions.com/wp-content/uploads/2012/09/The-NMDA-Receptor1-1024x872.jpg Graphic 1] - <font color="red">note the reference to Ketamine!</font>
** [https://www.ncbi.nlm.nih.gov/books/NBK11084/figure/A404/?report=objectonly Graphic 2] - note the comment about [http://brenda-enzymes.org/php/result_flat.php4?ecno= serine transhydroxy methylase] in Figure 6.10 !
* amphetamine-induced locomotor hyperactivity: A criteria for employee selection in Quebec ?
** Topic is [http://en.wikipedia.org/wiki/Voluntary_slavery Voluntary Slavery]:
*** is their any better drug than Ketamine to turn someone into a schizophreniac and accept <u>self-enslavement contracts</u>?  [[User:Etienne_Robillard|-ER]]
* Chair conformational disubstitution of chloride-dependent Ketimine [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff base]]: GlyT1 is a chloride-dependent ion transporter, therefore require a chloride hydroxyl anion to synthetize Glycine, unlike GABA, which activates upon Calcium-dependent ion transporter named Ca2+. [[User:Etienne_Robillard|-ER]]
* Active methylene enolates note: a b-keto-ester compound  (synthetic intermediate) with important pharmacological properties. Unlike a anti-depressor (ie: delta9-tetrahydrocannabinol), active-methylene enolates may be used for atypical neuroleptic-based chemotherapy. Note: You might be interested to read further on the functions of <u>selective serotonin uptake inhibitors (SSRI)</u> in particular '''Methylphenidate''' to understand the role of GABA in regulation of interneurons circuits. Moreover, this important finding might have serious implications on the method which the drug is delivered to the brain of humans exposed themselves to the undisclosed synthetic agent without their awareness or consent. Hence the population of Montreal and Quebec should be informed about the release and delivery of experimental pharmacological agents into the atmosphere may readily affect their cognitive reasoning capacities, including in particular the capacity to express logical thoughts from long-distance appearing objects. See also [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [[User:Etienne_Robillard/Notebook/30C6HSL|30C6HSL]].
=== See also ===
* [[User:Etienne_Robillard/Notebook/Phenothiazine|Phenothiazine]]
=== Did you know? ===
"Perhaps the most valuable result of all education is the ability to make yourself do the thing you have to do, when it ought to be done, whether you like it or not; it is the first lesson that ought to be learned; and however early a man's training begins, it is probably the last lesson that he learns thoroughly." -Thomas Henry Huxley
"People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf."
- George Orwell

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