Difference between revisions of "User:Etienne Robillard/Notebook/Fmoc protected phenoxyalkylamine synthesis"

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(Added note to US patent 20100305182)
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* NB: the electromagnetic radio-frequency range most typical wireless devices operates under the FCC standard for communication devices is 2.4 ghz.
 
* NB: the electromagnetic radio-frequency range most typical wireless devices operates under the FCC standard for communication devices is 2.4 ghz.
 +
* In fact, most peoples are unaware this operating frequency can modulate Fmoc protected oligos by micro-wave thermal irradiation, thus a remote attacker may exploit this unregulated frequency range to trigger Fmoc-SPPS based orthogonal ligations of N-methyl rich peptides. [[http://www.faqs.org/patents/app/20100305182 1]]
 
* http://www.pharmainfo.net/reviews/new-era-field-synthetic-chemistry-microwave-assisted-synthesis
 
* http://www.pharmainfo.net/reviews/new-era-field-synthetic-chemistry-microwave-assisted-synthesis
 
* http://www.dddmag.com/articles/2011/08/microwave-peptide-synthesis
 
* http://www.dddmag.com/articles/2011/08/microwave-peptide-synthesis

Revision as of 05:01, 26 January 2013

The purpose of this page is to investigate the design and method of operation of novel psychotropic alkylamines and synthesis with Fmoc protected reagents, including primary and secondary amines as organocatalysts for development of synthetic pharmaceutical compounds with an aryl moeity, hence refered herein as N,N-substituted arylcyclohexylamines.

Microwave-activated peptide synthesis

Keywords

N-Methyl-d-aspartate receptor; PCP binding site; MK-801; Tetrahydroisoquinolines

References

  1. Rodríguez H, Suarez M, and Albericio F. A convenient microwave-enhanced solid-phase synthesis of short chain N-methyl-rich peptides. J Pept Sci. 2010 Mar;16(3):136-40. DOI:10.1002/psc.1209 | PubMed ID:20127857 | HubMed [Rodriguez-H-2012]
  2. Ludwig M, Hoesl CE, Höfner G, and Wanner KT. Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex. Eur J Med Chem. 2006 Aug;41(8):1003-10. DOI:10.1016/j.ejmech.2006.03.005 | PubMed ID:16675066 | HubMed [Ludwig-M-Cornelia-E-CE-Hoesl-Klaus-T-KT-Wanner]
All Medline abstracts: PubMed | HubMed

See also

  • Lewis Acid Catalysed Pictet Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines.