Difference between revisions of "User:Etienne Robillard/Notebook/Fmoc protected phenoxyalkylamine synthesis"

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The purpose of this page is to investigate the design and method of operation of novel psychotropic
alkylamines and synthesis with Fmoc protected reagents, including primary and secondary amines
as organocatalysts for development of synthetic pharmaceutical compounds with an aryl moeity, hence
refered herein as N,N-substituted arylcyclohexylamines.
=== Microwave-activated peptide synthesis ===
* NB: the electromagnetic radio-frequency range most typical wireless devices operates under the FCC standard for communication devices is 2.45 GHz.
* In fact, most peoples are unaware this operating frequency can modulate Fmoc protected oligos by micro-wave thermal irradiation, thus a remote attacker may exploit this unregulated frequency range to trigger Fmoc-SPPS based orthogonal ligations of N-methyl rich peptides. [[http://www.faqs.org/patents/app/20100305182 1]]
* http://www.pharmainfo.net/reviews/new-era-field-synthetic-chemistry-microwave-assisted-synthesis
* http://www.dddmag.com/articles/2011/08/microwave-peptide-synthesis
* [http://host.madison.com/wsj/news/science/seely-on-science-chemical-agents-wage-war-against-bacteria/article_b5e25710-ed70-11e1-8e6b-0019bb2963f4.html Chemical agents wage war against owners of wireless communication devices operating in the 2.45 GHz spectrum]
* From gun control to wireless control, unregulation of the S-band frequency is not without risks of abuses from bioterrorists to develop dual-purposes, synthetic bioweapons: http://nanopatentsandinnovations.blogspot.se/2009/11/microwave-manufactures-semiconductor.html
** '''"The microwave reactor operates at 2.45 GHz and can be adapted to a continuous flow or autosampler system. "'''
=== Keywords ===
N-Methyl-d-aspartate receptor; PCP binding site; MK-801; Tetrahydroisoquinolines, AHL, NAND gate, Inverter
=== References ===
#Rodriguez-H-2012 pmid=20127857
#Ludwig-M-Cornelia-E-CE-Hoesl-Klaus-T-KT-Wanner pmid=16675066
=== See also ===
* Lewis Acid Catalysed Pictet Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines.

Latest revision as of 02:37, 30 April 2017

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