Difference between revisions of "User:Etienne Robillard/Notebook/Fmoc protected phenoxyalkylamine synthesis"

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(Added note to US patent 20100305182)
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The purpose of this page is to investigate the design and method of operation of novel psychotropic
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{{deleteme}}
alkylamines and synthesis with Fmoc protected reagents, including primary and secondary amines
 
as organocatalysts for development of synthetic pharmaceutical compounds with an aryl moeity, hence
 
refered herein as N,N-substituted arylcyclohexylamines.
 
 
 
=== Microwave-activated peptide synthesis ===
 
 
 
* NB: the electromagnetic radio-frequency range most typical wireless devices operates under the FCC standard for communication devices is 2.4 ghz.
 
* In fact, most peoples are unaware this operating frequency can modulate Fmoc protected oligos by micro-wave thermal irradiation, thus a remote attacker may exploit this unregulated frequency range to trigger Fmoc-SPPS based orthogonal ligations of N-methyl rich peptides. [[http://www.faqs.org/patents/app/20100305182 1]]
 
* http://www.pharmainfo.net/reviews/new-era-field-synthetic-chemistry-microwave-assisted-synthesis
 
* http://www.dddmag.com/articles/2011/08/microwave-peptide-synthesis
 
 
=== Keywords ===
 
 
 
N-Methyl-d-aspartate receptor; PCP binding site; MK-801; Tetrahydroisoquinolines
 
 
 
=== References ===
 
 
 
<biblio>
 
#Rodriguez-H-2012 pmid=20127857
 
#Ludwig-M-Cornelia-E-CE-Hoesl-Klaus-T-KT-Wanner pmid=16675066
 
</biblio>
 
 
 
=== See also ===
 
 
 
* Lewis Acid Catalysed Pictet Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines.
 

Latest revision as of 02:37, 30 April 2017

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