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__TOC__
 
  
'''This page is old! For updated info on Agent E.coli see this [http://openwetware.org/index.php?title=User:Etienne_Robillard/Notebook/Agent_Ecoli page].'''
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{{LnNotebookRecentChanges2}}
  
The project is currently licensed under [http://www.gnu.org/copyleft/fdl.html GNU Free Documentation License Version 1.3].
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__TOC__
  
== License ==
+
== Hypothesis ==
 +
1. Unilateral/clandestine solar geoengineering activity is a source of air pollution/particulate matter. ('''PM2.5''')
  
Copyright (C)  2012 Etienne Robillard
+
2. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.
  
Permission is granted to copy, distribute and/or modify this document
+
3. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, stress-induced neuroinflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite>
Under the terms of the GNU Free Documentation License, Version 1.3
 
or any later version published by the Free Software Foundation;
 
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
 
A copy of the license is included in the section entitled "GNU Free Documentation License".
 
 
 
== Contents ==
 
 
 
 
 
 
 
=== Abstract ===
 
 
 
Chemtrails is a recent phenomenon I started to observe around 2009.
 
 
 
At this time I had very little knowledge about geoengineering or even
 
basic chemistry. I then started to familiarize myself with such phenomenons as they began to occupy further lines of
 
dissipated white lines across unaffected clouds. I then further observed the phenomenon, and noted down the dates
 
of such "phenomenons" taking guess on their physical attributes and noticed they were from man-operated aircrafts or some kind of cloaked
 
aerial origin. (geoengineering, synthetic biology)
 
 
WW2 (World war 2) was for me a couple of popular American movie scenes including films and other things dealing with Jews being intoxicated with
 
poisonous gas in concentration camps. I was not very interested in them and neither in the chemotherapy eugenic "science" which resulted in thousands
 
of deaths. (chemotherapy)
 
  
=== Synopsis ===
+
4. TLR4 activation is implicated in the dopaminergic neurotoxicity of chronic PM2.5 exposure. <cite>Yao-2013</cite>
  
Welcome to the chemtrails scientific notebook version 1.0! The main goal and objective of this wiki is to inform and educate the reader to the inherent ethical and scientific issues with aerosol-based spraying over domestic populations. Moreover, key evidences are put together to develop a theory about the implications of synthetic biology in the so-called geoengineering program and in particular for denying its existence to the general public.
+
== Differential effects of long-term exposure to PM2.5 ==
 +
=== Cardiovascular system ===
 +
* Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. <cite>Brook-2010</cite>
 +
** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite>
 +
** The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. <cite>Liu-2016</cite>
 +
* Dysregulation of miRNA expression levels. <cite>Lu-2015</cite>
  
=== Credits ===
+
=== Central nervous system ===
 +
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite>
 +
* Parkinson disease <cite>Levesque-2013</cite>
 +
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
 +
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite>
 +
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite>
 +
* Microglia-mediated dopaminergic neurotoxicity. <cite>Levesque-2013</cite>
 +
** TLR4 signaling mediate microglial activation
  
TODO
+
=== Endocrine system ===
 +
* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite>
 +
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite>
 +
* Autoimmune disorders <cite>Bernatsky-2016</cite>
  
=== History ===
+
=== Epigenetic system ===
 +
* Differential DNA methylation <cite>Brennan-2016</cite>
  
TODO
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=== Limbic system ===
 +
* Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. <cite>Chao-2017</cite>
  
=== Preliminary Results and Dataset ===
+
=== Lymphatic system ===
 +
* Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite>
  
# Hard evidences tying synthetic biology to the rogue and repeated chemical warfare (CW) spraying operations over domestic populations were found and analyzed. So far our observations provides empirical
+
=== Respiratory system ===
data to demonstrate a clear and directed relationship between each components of a orthogonal biological circuit to induce horizontal genetic modifications (HGT) in unaware human populations.
+
* AECOPD <cite>Lei-2015</cite>
# Thus it appears likely the method of operation of the clandestine aerosol spraying operations are part of a larger, state-sponsored bioterrorism program or orthogonal platform for human-based experimentations with novel psychotropic pharmaceutical-grade compounds, including Ketamine, Arylcyclohexylamines derivatives, MK-801, PCP, and 1,2,3,4-substituted tetrahydroisoquinolines analogs.
+
* Lung cancer <cite>Hamra-2014</cite>
# In addition, the nature and origins of theses synthetic compounds have been associated to German pharmaceutical companies which were also active during the Nazi regime, thus raising fundamental and unanswered questions on the dual-purpose functions associated to theses chemical agents.
 
 
==== Synthetic deoxyoligonucleotide assembly using enantioselective phosphoramidites (cDNA/DNA/RNA polymerase II) ====
 
  
* Furthermore, the role of the LuxR gene and part BBa_F2620 suggests a functional system to activate HGT upon light induced signals and from an inducible chemical promoter known as L-Beta-Arabinose (pBAD).
+
== Nanotoxicity of functionalized metallic nanoparticles ==
* Keywords: DNA, chromatin, purines, oligonucleotides, phosphoramidites
+
How to determine nanotoxicity potential of metallic nanoparticles using computational
 +
simulation of chronic PM2.5 exposure?
 +
* Gold nanoparticles (AuNP)
 +
* Silica nanoparticles (SiNP)
 +
* Silver
  
==== cDNA synthesis using deoxynucleoside phosphoramidite derived reagents ====
+
== Notes ==
 
+
* Condensation aerosols:
* The use of benzilic-like reagents (benzaldehyde, benzoic acid) and 1 2-cyanoethyl group (acetonitrile)  are in addition believed to be employed as organocatalysts (phosphotransferase) to increase the effectiveness of the administred compound or drug, and facilitate inter-species gene transfer using the LacZ operon (b-galactosidase) and activate high-throughput RNA transcription. (RNA type-II polymerase)
+
** [http://iopscience.iop.org/article/10.1070/RC1965v034n02ABEH001418/pdf Monodisperse aerosols]
 
+
* Coal-Based Jet Fuels:
== Quotes by topic ==
+
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels]
 
+
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program]
Deceit and disinformation:
+
** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research]
* "During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
+
** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials]
 
+
* Open Questions:
Duty:
+
** [https://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?]
* "We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill
+
** [https://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
* "We have now sunk to a depth at which restatement of the obvious is the first duty of intelligent men." -- George Orwell
+
** [https://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?]
* "It is no use saying, 'We are doing our best.' You have got to succeed in doing what is necessary." -- Winston Churchill
+
** [https://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?]
 
+
** [https://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?]
Courage:
+
** [https://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?]
* "You have enemies? Good. That means you've stood up for something, sometime in your life." -- Winston Churchill
+
* New Theories:
* "What kind of people do they think we are? Is it possible they do not realize that we shall never cease to persevere against them until they have been taught a lesson which they and the world will never forget?" -- Winston Churchill
+
** [https://www.thenakedscientists.com/forum/index.php?topic=69963 Effects of geoengineering on the limbic system]
* [http://openwetware.org/images/6/66/Science_in_the_city_2-02.png "All free men, wherever they may live, are citizens of Berlin. And therefore, as a free man, I take pride in the words "Ich bin ein Berliner!" -- John F. Kennedy]
+
* Documentation:
 
+
** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)]
Science:
+
** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)]
* "A central lesson of science is that to understand complex issues (or even simple ones), we must try to free our minds of dogma and to guarantee the freedom to publish, to contradict, and to experiment. Arguments from authority are unacceptable." -- Carl Sagan
+
** [https://en.wikipedia.org/wiki/TLR4 TLR4 (Wikipedia)]
 +
** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase]
 +
** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)]
 +
** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)]
 +
** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)]
  
 
== Resources ==
 
== Resources ==
* [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/Brainstorming Brainstorming]
+
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Introduction|Introduction]]
* [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/Wordlist Wordlist]
+
* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
* [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/EGFR EGFR]
+
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Model|Model]]
 +
* [[User:Etienne_Robillard/Notebook/Photographic_evidences|Photographic evidences]]
 +
* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Research|Research]]
  
* Agent E.coli:
+
== Keywords ==
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/Agent%20Ecoli:Introduction Agent Ecoli:Introduction to Agent E.coli] : A mutant lifeform (genome) designed to restate and reaffirm your insanity of living emprisonated into a creed of lies in exchange of your liberty, consciousness, and love for yourself.
+
aerosol, bioaerosol, functionalized nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, gold, microglia, MAC1, monodisperse aerosol, condensation,  
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/Agent_Ecoli:PhosphohistidineTransferaseComponent Agent Ecoli:PhosphohistidineTransferaseComponent] : a recombinant DNA-protein ligase is not unbreakable per se and can be degraded with phosphorus-degrading enzymes in a catalytic process known as N-methyl nucleosidase synthesis. The Phosphohistidine transferase enzyme (2.7.13.3) is activated from dual-input inducible promoters forming DNA acid with phosphorus-bound nucleosides, namely ATP (Adenosine 5'-triphosphate) and cAMP (CRP). So to break a synthetic ATP ligand, one must perhaps first break the chiral P-N bond to create energy (ATP) for the brain and allow CNP to participate in the phosphorus degradation. 
+
drug delivery, TLR4
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/Agent%20Ecoli:PhotoReceptorComponent Agent Ecoli:PhotoreceptorComponent] : The photoreceptor component of Agent E. coli (Agent Cocaine) may be closely associated to the mAChr receptor, a neurotransmitter with high-affinity for acetylcholinesterase inhibition found in many toxic nerve agents used for chemical warfare, which are blocking the mAchr receptor to phosphorylate, thus producing plaques of b-amyloids toxic aggregates in the hippocampus and amygdala regions, short-circuiting your consciousness to express feelings and emotions apart when asking you to resolve 2+2=5. 
 
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/Agent_Ecoli:Plasmid_cloning_vectors_for_gene_therapy_with_phosphohistidine_based_oligos Agent Ecoli:Plasmid cloning vectors for gene therapy with phosphohistidine based oligos]
 
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/ProjectBareBackMountain Agent Ecoli:ForensicEvidencesChart]: Current synthesis and results triage project
 
  
* Miscellanous:
 
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Notebook/Chemtrails911%20notebook/NK603 NK603] : Eugenics now in gene form!
 
** [http://www.openwetware.org/wiki/User:Etienne%20Robillard/Competent_cells/HEK_293 HEK 293] : Are Human Embryonic Kidney cells lineage a hazard for your health ?
 
  
== See also ==
 
  
Biology:
+
== References ==
* [http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html Pineal Gland and Melatonin]
+
<biblio>
* [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch08/ch8-8.html Solvents Effects]
+
#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
* [http://www.medwelljournals.com/fulltext/?doi=javaa.2011.1895.1900 Modes of Action of Probiotics: Recent Developments]
+
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
* Amino acids:
+
#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf
** [http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit4/antigens/antigens.html The Adaptive Immune System: Antigens]
+
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
** [http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html The Chemistry of Amino Acids]
+
#Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611
** [http://toxsci.oxfordjournals.org/content/76/1/131/F1.large.jpg Fatty Acid Amide Hydrolase]
+
//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
* Genetic acquisitions of synthetic like antigens (ie: vaccine escape evidences)
+
#Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016
** [http://pf11.blogspot.com/2010/03/zoonotic-h9n2-avian-influenza-further.html "The truth is in the sequences."]
+
//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
** [http://www.lewrockwell.com/sardi/sardi133.html Why Isn't the H1N1 Pandemic Flu Being Investigated as a Designed Bioweapon?]
+
#Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992
** [http://anthro.palomar.edu/mendel/mendel_3.htm Basic Principles of Genetics: Exceptions to Simple Inheritance] (non-Mendelian inheritance)
+
//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
** [http://www.mendeley.com/research/highly-pathogenic-avian-influenza-virus-h5n1-egypt-escapes-vaccineinduced-immunity-confers-clinical-protection-against-heterologous-clade-22-1-egyptian-isolate/ Highly pathogenic avian influenza virus H5N1 from Egypt escapes vaccine-induced immunity but confers clinical protection against a heterologous clade 2.2.1 Egyptian isolate.]
+
#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
 +
//Fine particulate matter in acute exacerbation of COPD.
 +
#Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630
 +
//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
 +
#Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161
 +
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
 +
#Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876
 +
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
 +
#Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831
 +
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
 +
#Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521
 +
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
 +
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714
 +
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.
 +
#Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041
 +
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
 +
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/
 +
//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
 +
#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/
 +
//The Effects of Nanomaterials as Endocrine Disruptors.
 +
#Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428
 +
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
 +
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/
 +
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
 +
#Chao-2017 https://www.ncbi.nlm.nih.gov/pubmed/27539004
 +
//Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.
 +
#Liu-2016 https://www.ncbi.nlm.nih.gov/pubmed/26580727
 +
//The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.
 +
#Bernatsky-2016 https://www.ncbi.nlm.nih.gov/pubmed/25988990
 +
//Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.
 +
#Lu-2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/
 +
//Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
 +
#Brennan-2016 https://www.ncbi.nlm.nih.gov/pubmed/27453791
 +
//Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study.
 +
#Yao-2013 https://www.ncbi.nlm.nih.gov/pubmed/23388509
 +
//Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia.
 +
</biblio>
  
Synthetic Biology:
+
== License ==
* [http://www.organicconsumers.org/articles/article_20878.cfm ETC Group calls for Global Moratorium on Synthetic Biology]
 
  
Peoples:
+
Copyright (C)  2012-2017 Etienne Robillard
* [http://keith.seas.harvard.edu/FICER.html Fund for Innovative Climate and Energy Research]
 
* [http://caseclosedbylewweinstein.wordpress.com/2009/06/28/tracking-dr-ivins%E2%80%99-rmr-1029-anthrax-more-questions-for-um-and-lsu-researchers/ tracking Dr. Ivins’ RMR-1029 anthrax; more questions for UM and LSU researchers]
 
** [http://caseclosedbylewweinstein.wordpress.com/2012/05/09/april-2012-fbi-quantico-publication-the-detection-of-meglumine-and-diatrizoate-in-the-mailed-anthrax-in-no-way-pointed-to-bruce-ivins-as-the-perpetrator-or-involved-at-all-meglumine-and-diatrizo/ April 26, 2012 FBI Quantico Publication: The Detection of Meglumine and Diatrizoate In No Way Pointed To Bruce Ivins As The Perpetrator Or Involved At All; Meglumine and Diatrizoate were both detected in the USAMRIID RMR 1029 sample — but '''Meglumine and Diatrizoate were NOT detected in the 2001 letter''' spore evidence]
 
* [http://cns.miis.edu/wmdjunction/110822_fbi_anthrax.htm New Questions About the FBI's Anthrax Case: Valid Concerns or Red Herring?]
 
* [http://usasurvival.org/ck03.25.10.html Obama Obstructs Oversight of FBI in Anthrax Case]
 
* [http://killerspray.com/blog?post=Teen_SofiaXenidis_call2_action Sofia Xenidis Testimonial and Call for Actions]
 
  
Wikipedia:
+
Permission is granted to copy, distribute and/or modify this document
* [http://en.wikiversity.org/wiki/Introduction_to_psychology/Consciousness Introduction to psychology: Consciousness]
+
Under the terms of the GNU Free Documentation License, Version 1.3
 
+
or any later version published by the Free Software Foundation;
== Recent news ==
+
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
* [http://luckslab.org/team/NEWS/Entries/2012/11/1_Julius_win_Gates_Grand_Challenge_Exploration_Grant_with_Jeremy_Thompson_and_Keith_Perry!.html Julius wins Gates Grand Challenge Exploration Grant with Jeremy Thompson and Keith Perry!] 2012/11/01
+
A copy of the license is included in the section entitled "GNU Free Documentation License".
* [http://www.deathofevidence.ca/ Celebrating the Death Of Evidence in Canada Scientific Research Funds: No science, no evidence, no truth, no democracy]
 
 
 
* [http://www.nature.com/news/remote-controlled-genes-trigger-insulin-production-1.10585 Remote-controlled genes trigger insulin production]
 
** [[User:Etienne Robillard|Etienne Robillard]] 07:18, 5 May 2012 (EDT): Whoa, calmodulin mediated signal transduction using fat-soluble nanoparticles aggregating to tumor cells in a "controlled/directed" process using heat/light energy as the master switch for tyrosine kinase II to induce or inhibit (auto)phosphorylation of pTyr residues?
 
* [http://www.naturalnews.com/034906_Bill_Gates_geo-engineering_chemtrails.html Bill Gates exposed for funding research, promotion of spraying geo-engineered 'chemtrails' across globe], 2012/02/08
 
* [http://www.crainsdetroit.com/article/20110803/FREE/110809957 NanoBio gets license from agency to develop vaccine to fight respiratory syncytial virus infections], 2011/08/03
 
* [http://www.sciencedaily.com/releases/2010/09/100930142727.htm Microbes Engineered for Low-Cost Production of '''Anti-Cancer''' Drug, Taxol], 2010
 
* [http://www.azonano.com/news.aspx?newsID=15165 GSK and NanoBio Signs Exclusive Over-the-Counter Licensing Agreement for Nanoemulsion Treatment], 2009/12/16
 
* [http://www.schizophreniaforum.org/new/detail.asp?id=1413 Does Oxidative Stress Link NMDA and GABA Hypotheses of Schizophrenia?] ([http://www.sciencedirect.com/science/article/pii/S0304394008010197 Study]), 2007/12/09
 
* [http://phys.org/news7764.html Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates], 2005/11/01
 
* [http://www.thefreelibrary.com/BattellePharma+to+Present+At+Respiratory+Drug+Delivery+VIII...-a085494227 BattellePharma to Present At Respiratory Drug Delivery VIII Conference.], 2002/05/07
 
* [http://www.nytimes.com/2001/09/04/world/us-germ-warfare-research-pushes-treaty-limits.html U.S. Germ Warfare Research Pushes Treaty Limits], 2001/09/04
 
  
  
 +
__NOTOC__
  
----
+
== See you in space cowboy ==
  
{{LnNotebookRecentChanges2}}
+
<blockquote>
 +
"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them.
 +
I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein
 +
</blockquote>
  
 +
<blockquote>
 +
"The essence of the independent mind lies not in what it thinks, but in how it thinks."
 +
― Christopher Hitchens
 +
</blockquote>
  
__NOTOC__
+
<blockquote>"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
 +
</blockquote>
  
My dear friend, how would you be such a clever scientist without spraying unaware citizens in the wild? The device you designed at school would not even operate properly...
+
<blockquote>"Under our noses, over our heads, hidden in plain [https://www.reddit.com/r/chemtrails/comments/609s8u/experimental_evidences_linking_clandestine/ sight]..." - Anonymous</blockquote>

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Hypothesis

1. Unilateral/clandestine solar geoengineering activity is a source of air pollution/particulate matter. (PM2.5)

2. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.

3. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, stress-induced neuroinflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]

4. TLR4 activation is implicated in the dopaminergic neurotoxicity of chronic PM2.5 exposure. [2]

Differential effects of long-term exposure to PM2.5

Cardiovascular system

  • Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. [3]
    • Increase in blood pressure (hypertension) [4]
    • The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. [5]
  • Dysregulation of miRNA expression levels. [6]

Central nervous system

  • Alzheimer disease [7][8]
  • Parkinson disease [8]
  • PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [9][10][11][12]
  • PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [10][13]
  • Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [14]
  • Microglia-mediated dopaminergic neurotoxicity. [8]
    • TLR4 signaling mediate microglial activation

Endocrine system

  • Decrease of serum testosterone levels [15]
  • Increase of serum estradiol levels [15]
  • Autoimmune disorders [16]

Epigenetic system

  • Differential DNA methylation [17]

Limbic system

  • Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. [18]

Lymphatic system

  • Lipid peroxidation and oxidative DNA/RNA damage. [19]

Respiratory system

  • AECOPD [9]
  • Lung cancer [20]

Nanotoxicity of functionalized metallic nanoparticles

How to determine nanotoxicity potential of metallic nanoparticles using computational simulation of chronic PM2.5 exposure?

  • Gold nanoparticles (AuNP)
  • Silica nanoparticles (SiNP)
  • Silver

Notes

Resources

Keywords

aerosol, bioaerosol, functionalized nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, gold, microglia, MAC1, monodisperse aerosol, condensation, drug delivery, TLR4


References

  1. https://www.ncbi.nlm.nih.gov/pubmed/15061611 [Gilmour-2004]
    Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
  2. https://www.ncbi.nlm.nih.gov/pubmed/23388509 [Yao-2013]
    Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia.
  3. https://www.ncbi.nlm.nih.gov/pubmed/20458016 [Brook-2010]
    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ [Balasubramanian-2013]
    Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
  5. https://www.ncbi.nlm.nih.gov/pubmed/26580727 [Liu-2016]
    The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/ [Lu-2015]
    Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
  7. https://www.ncbi.nlm.nih.gov/pubmed/25310992 [Jung-2015]
    Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ [Levesque-2013]
    The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
  9. http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full [Lei-2015]
    Fine particulate matter in acute exacerbation of COPD.
  10. https://www.ncbi.nlm.nih.gov/pubmed/25913161 [Liu-2015]
    Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
  11. https://www.ncbi.nlm.nih.gov/pubmed/21506876 [Riva-2011]
    Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
  12. https://www.ncbi.nlm.nih.gov/pubmed/21561831 [Levesque-2011]
    Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
  13. https://www.ncbi.nlm.nih.gov/pubmed/21724521 [Morgan-2011]
    Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
  14. https://www.ncbi.nlm.nih.gov/pubmed/18349428 [Solt-2008]
    Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
  15. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ [Lavicoli-2013]
    The Effects of Nanomaterials as Endocrine Disruptors.
  16. https://www.ncbi.nlm.nih.gov/pubmed/25988990 [Bernatsky-2016]
    Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.
  17. https://www.ncbi.nlm.nih.gov/pubmed/27453791 [Brennan-2016]
    Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study.
  18. https://www.ncbi.nlm.nih.gov/pubmed/27539004 [Chao-2017]
    Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.
  19. https://www.ncbi.nlm.nih.gov/pubmed/27321041 [Ambroz-2016]
    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
  20. https://www.ncbi.nlm.nih.gov/pubmed/24911630 [Hamra-2014]
    Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
  21. http://www.mdpi.com/1660-4601/12/8/9375/htm [Herndon-2015]
    Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
  22. http://nuclearplanet.com/frontiers1.pdf [Herndon-2016]
    Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
  23. http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 [Cheng-2010]
    Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.

License

Copyright (C) 2012-2017 Etienne Robillard

Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".



See you in space cowboy

"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them. I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein

"The essence of the independent mind lies not in what it thinks, but in how it thinks." ― Christopher Hitchens

"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
"Under our noses, over our heads, hidden in plain sight..." - Anonymous