User:Tkadm30/Notebook/Arylcyclohexylamines/2013/05/24: Difference between revisions
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=== Did you know ? === | === Did you know ? === | ||
<blockquote>“Whenever the will to power falls off in any way, there will also be physiological decline, decadence. And when the most masculine virtues and drives have been chopped off the god of decadence, he will necessarily turn into a god of the physiologically retrograde, the weak.” – Friedrich Nietzsche [http://euro-synergies.hautetfort.com/archive/2012/11/22/nietzsche-physiology-transvaluation.html Link]</blockquote> | <blockquote>“Whenever the will to power falls off in any way, there will also be physiological decline, decadence. And when the most masculine virtues and drives have been chopped off the god of decadence, he will necessarily turn into a god of the physiologically retrograde, the weak.” – Friedrich Nietzsche - [http://euro-synergies.hautetfort.com/archive/2012/11/22/nietzsche-physiology-transvaluation.html Link]</blockquote> |
Revision as of 17:47, 10 July 2013
A jolie passage
.cell
- Calcium chloride (CaCl2) != potassium chloride [Ca2+]
- potassium chloride = food additive
- potassium chloride = KCl (anhydrous) [Cl-]
- KCl (-) mediated CREB1 gene expression: ($35.95)
- Keywords: CREB1, NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine
Orthogonal serine/threonine-specific GSK-3 inhibitors
- i found this paper worth the mention (2013): http://www.sciencedirect.com/science/article/pii/S0092867413002857 ($31.50)
- NMDA dependent cell adhesion (binding) notes
- c-fos: http://www.uniprot.org/uniprot/P01100
- CREB2: http://www.genome.jp/dbget-bin/www_bget?hsa:468
- NMDAR1: http://www.kegg.jp/dbget-bin/www_bget?hsa:2902
- You may want to view/download the uniprot datasets here and here.
- Keywords: GSK-3, breast cancer (PKB), Glycine, Wnt signaling pathway
- See also this free PMC article about the GSK-3 kinase here.
Notes
- Désactivation sélective du récepteur NMDAR1 (Ser133?)
- Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]
References
- Macías W, Carlson R, Rajadhyaksha A, Barczak A, and Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 2;890(2):222-32. DOI:10.1016/s0006-8993(00)03163-2 |
- De Cesare D, Jacquot S, Hanauer A, and Sassone-Corsi P. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12202-7. DOI:10.1073/pnas.95.21.12202 |
- Du K and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4;273(49):32377-9. DOI:10.1074/jbc.273.49.32377 |
- Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, and McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994 Sep;14(9):6107-16. DOI:10.1128/mcb.14.9.6107-6116.1994 |
- Lee HJ, Mignacca RC, and Sakamoto KM. Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. J Biol Chem. 1995 Jul 7;270(27):15979-83. DOI:10.1074/jbc.270.27.15979 |
Did you know ?
“Whenever the will to power falls off in any way, there will also be physiological decline, decadence. And when the most masculine virtues and drives have been chopped off the god of decadence, he will necessarily turn into a god of the physiologically retrograde, the weak.” – Friedrich Nietzsche - Link