Difference between revisions of "User:Etienne Robillard/Notebook/Arylcyclohexylamines/2013/05/24"

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(Orthogonal serine/threonine-specific GSK-3 inhibitors)
(4-methylamino carboxilic protection group: Fast and versatile conversion of methylamide esters in presence of a nucleophilic Schiff base (reduktiv))
 
(One intermediate revision by the same user not shown)
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* See also: [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion NMDA dependent cell adhesion] (aka the Wnt (Calcium Binding) pathway), Shikimate pathway
 
* See also: [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion NMDA dependent cell adhesion] (aka the Wnt (Calcium Binding) pathway), Shikimate pathway
  
=== 4-methylamino carboxilic protection group: Fast and versatile conversion of methylamide esters in presence of a nucleophilic Schiff base (reduktiv) ===
+
=== 4-methylamino carboxilic protection: Fast and versatile conversion of C-(2-phenyl-cyclohexyl) methylamide esters in presence of a nucleophilic Schiff base (reduktiv) ===
  
 
# [http://de.wikipedia.org/wiki/Schutzgruppe#Amine PMB]
 
# [http://de.wikipedia.org/wiki/Schutzgruppe#Amine PMB]
# [http://onlinelibrary.wiley.com/doi/10.1002/anie.197805691/ 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)]  
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# [http://onlinelibrary.wiley.com/doi/10.1002/anie.197805691/ 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)]
 +
# Significant papers (Topic: microwave induced methylphenidate HCl synthesis)
 +
## [http://www.google.com/patents/US20100249225 C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders]
 +
# Keywords: tau protein hyperphosphorylation, Alzheimer Disease, MK-801
  
=== Orthogonal serine/threonine-specific GSK-3 inhibitors ===
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=== Orthogonal serine/threonine-specific GSK3 inhibitors ===
  
 
* i found this paper worth the mention (2013): http://www.sciencedirect.com/science/article/pii/S0092867413002857 ($31.50)
 
* i found this paper worth the mention (2013): http://www.sciencedirect.com/science/article/pii/S0092867413002857 ($31.50)
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* NMDAR1: http://www.kegg.jp/dbget-bin/www_bget?hsa:2902
 
* NMDAR1: http://www.kegg.jp/dbget-bin/www_bget?hsa:2902
 
* You may want to view/download the uniprot datasets [http://www.uniprot.org/uniprot/P16220 here] and [http://www.uniprot.org/uniprot/P31749 here].  
 
* You may want to view/download the uniprot datasets [http://www.uniprot.org/uniprot/P16220 here] and [http://www.uniprot.org/uniprot/P31749 here].  
* Keywords: GSK-3, breast cancer (PKB), Glycine, Wnt signaling pathway, Alzheimer Disease
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* Keywords: GSK3, breast cancer (PKB), Glycine, Wnt signaling pathway, Alzheimer Disease
* See also this free PMC article about the GSK-3 kinase [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006448/?report=classic here].
+
* See also this free PMC article about the GSK3 kinase [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006448/?report=classic here].
  
 
=== Notes ===
 
=== Notes ===

Latest revision as of 17:14, 29 July 2013

A jolie passage

  • Calcium chloride (CaCl2) != potassium chloride [Ca2+]
  • potassium chloride = food additive
  • potassium chloride = KCl (anhydrous) [Cl-]
  • KCl (-) mediated CREB1 gene expression: ($35.95)
  • Keywords: CREB1, NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine (Ketamine), Serine (phosphorylation), orthogonal phenolic methylamide enolates, active methylenes enolates, metal-bound complexes, -rC=NOH, carbenes (NHC), 4-methylimidazole derivatives (4-Mel, 4-methoxy (4-met), N-benzyl methylamine, pyridineN-methyl acylamino pyridine), Ethanolamine
  • See also: NMDA dependent cell adhesion (aka the Wnt (Calcium Binding) pathway), Shikimate pathway

4-methylamino carboxilic protection: Fast and versatile conversion of C-(2-phenyl-cyclohexyl) methylamide esters in presence of a nucleophilic Schiff base (reduktiv)

  1. PMB
  2. 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)
  3. Significant papers (Topic: microwave induced methylphenidate HCl synthesis)
    1. C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders
  4. Keywords: tau protein hyperphosphorylation, Alzheimer Disease, MK-801

Orthogonal serine/threonine-specific GSK3 inhibitors

Notes

  • Désactivation sélective du récepteur NMDAR1 (Ser133?)
    • Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]


References

  1. Macías W, Carlson R, Rajadhyaksha A, Barczak A, and Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 2;890(2):222-32. PubMed ID:11164788 | HubMed [CREB-2001]
  2. Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion [Li-Hanahan-1-2013]
  3. De Cesare D, Jacquot S, Hanauer A, and Sassone-Corsi P. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12202-7. PubMed ID:9770464 | HubMed [CREB-1998]
  4. Du K and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4;273(49):32377-9. PubMed ID:9829964 | HubMed [CREB-1998]
  5. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, and McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994 Sep;14(9):6107-16. PubMed ID:8065343 | HubMed [CREB-1994]
  6. Lee HJ, Mignacca RC, and Sakamoto KM. Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. J Biol Chem. 1995 Jul 7;270(27):15979-83. PubMed ID:7608156 | HubMed [CREB-1995]
All Medline abstracts: PubMed | HubMed

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