User:Etienne Robillard/Notebook/Arylcyclohexylamines/2013/05/24

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Revision as of 16:53, 29 July 2013 by Etienne Robillard (talk | contribs) (Orthogonal serine/threonine-specific GSK-3 inhibitors)
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A jolie passage

  • Calcium chloride (CaCl2) != potassium chloride [Ca2+]
  • potassium chloride = food additive
  • potassium chloride = KCl (anhydrous) [Cl-]
  • KCl (-) mediated CREB1 gene expression: ($35.95)
  • Keywords: CREB1, NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine (Ketamine), Serine (phosphorylation), orthogonal phenolic methylamide enolates, active methylenes enolates, metal-bound complexes, -rC=NOH, carbenes (NHC), 4-methylimidazole derivatives (4-Mel, 4-methoxy (4-met), N-benzyl methylamine, pyridineN-methyl acylamino pyridine), Ethanolamine
  • See also: NMDA dependent cell adhesion (aka the Wnt (Calcium Binding) pathway), Shikimate pathway

4-methylamino carboxilic protection group: Fast and versatile conversion of methylamide esters in presence of a nucleophilic Schiff base (reduktiv)

  1. PMB
  2. 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)

Orthogonal serine/threonine-specific GSK-3 inhibitors

Notes

  • Désactivation sélective du récepteur NMDAR1 (Ser133?)
    • Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]


References

  1. Macías W, Carlson R, Rajadhyaksha A, Barczak A, and Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 2;890(2):222-32. PubMed ID:11164788 | HubMed [CREB-2001]
  2. Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion [Li-Hanahan-1-2013]
  3. De Cesare D, Jacquot S, Hanauer A, and Sassone-Corsi P. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12202-7. PubMed ID:9770464 | HubMed [CREB-1998]
  4. Du K and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4;273(49):32377-9. PubMed ID:9829964 | HubMed [CREB-1998]
  5. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, and McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994 Sep;14(9):6107-16. PubMed ID:8065343 | HubMed [CREB-1994]
  6. Lee HJ, Mignacca RC, and Sakamoto KM. Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. J Biol Chem. 1995 Jul 7;270(27):15979-83. PubMed ID:7608156 | HubMed [CREB-1995]
All Medline abstracts: PubMed | HubMed

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