Difference between revisions of "User:Etienne Robillard/Notebook/Arylcyclohexylamines"

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== Introduction ==
The purpose of this notebook is to investigate the whys and wherefores of [[User:Etienne_Robillard/Notebook/chim_trills_notebook|Agent Scooby Doo]] in the product of N-benzylamine induced reactions
by comparitive study of psychotropic alkylamines drugs including '''Methylphenidate''' and Arylacetonitriles-derived alkylating solvents and their combined effects on
human [[User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion|NMDA receptor]] and also [[User:Etienne_Robillard/Notebook/GABA|GABA]].
== Psychotropic, optically-activated methylenes enolates (Amphetamine group) ==
=== Microwave activated (R,S)-Methylphenidate (Ritalin) synthesis ===
[[User:Etienne_Robillard/Notebook/Methylphenidate|Methylphenidate]] (trademark Ritalin) HCl is a [[User:Etienne_Robillard/Notebook/Piperidine|piperidine]] derived synthetic drug prescribed in the treatment of "schizophrenia" and "bipolar disorders" to childrens with chronic "ADHD" (Attention Deficit Hyperactivity Disorder) symptoms.
Methylphenidate (MP) compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by
the scientific community. [[http://en.wikipedia.org/wiki/Methylphenidate#Long-term_effects 1]]
Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in
chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy
of childrens with amphetamine-like drugs.  [[http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html 2]]
=== Side-effects of long-term Benzylamine-based drug delivery over unaware and disinformed Civilian populations ===
* Latent peripheral object recognition problems
* Amphetamine-induced psychosis (severe-like hallucinations)
* Aggressivity (in Male subjects)
* unrational thinking (in Female subjects)
* disproportional thinking
* chronic dermatitis signs (nb: a apparent sign of microwave-induced burns) [XXX]
* Increased alcoholism  [Benzylamine]
* <s>early-onset Parkinson Disease like symptoms [DS]</s>
* early-onset Alzheimer Disease like symptoms [AD]
* Locomotor hyperactivity [Benzylamine]
* S1PR4-induced Breast Cancer [S1PR4]
* Anxiety [Note: Althought some people might call this "schizophrenia", not sure why, unless for the medicamentation of anxiety with synthetic drugs, which is fairly odd, given that anxiety is a natural phenomenon humans feel when approaching the unknown, like in no particular order, how the women brain work to legitimate the consent of voluntary slavery, or perhaps synthetic biology, in manufacturing life, love, and empathy, obviously, when the lost of the former become an apparent phenotype, forcing psychiatrists and doctors to dismantle their own oath, in adopting unreasonable and dangerous attitudes, stubbornly labeling peaceful civilians a "schizophreniac", and obeying their apparently inner weaknesses prescribing lethal drugs to civilians who dare to affront the '''reality of science''' in all its gory pornographic details, thereby enslaving humans into clouds of electromagnetic waves for their own sicken purposes of wiring humans into addressable semi-conductors to name a few.] -[[User:Etienne_Robillard|ER]] (13.6.9)
* Metabolic disorders (Glutamate-specific?) [confirmed? validated?] -[[User:Etienne_Robillard|ER]] (13.7.23)
=== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramidates  ===
Student resources:
** http://euch6f.chem.emory.edu/arynes.html
** [http://www.chemguide.co.uk/organicprops/anhydrides/nitrogen.html Reactions of Ketones with Primary Amines]
** http://research.cm.utexas.edu/nbauld/CHAPTER%2021.htm
==== Arylcyclohexylamines and N-substituted cyclohexylaminopyrimidines derivatives ====
* Aryl ketones (4-trans substituted cyclohexylamines and 4-methoxy derived compounds)
** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
* "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
* "phosphines" and the [[Phosphohistidine_transferase|phosphohistidine (N-methyl)transferase]] enzyme.
** phosphoramidate based peptide and oligo "coupling" reagents...
** Imidazole and N-methyl imidazole (1-methylimidazole) : http://en.wikipedia.org/wiki/1-Methylimidazole
* N-substituted cyclohexylaminopyrimidines:
** E. coli K-12 W3110 (aka the pyrimidine starved strain...)
** See US5039692 - '''[http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Fmoc_protected_phenoxyalkylamine_synthesis Psychotropic phenoxyalkylamine derivatives and their uses in domestic/civilian experiments with synthetic opioid receptor agonists]''' (1,2-substituted thienopyrimidone)
*** View also [[Sulfanilamide]] - A compound which has been listed in the Doctor Trials of the Nuremberg nazi medical experiments [http://law2.umkc.edu/faculty/projects/ftrials/nuremberg/NurembergDoctorTrial.html 1]
* Keywords:
** cyanoethylation,arylcyclohexylamine,phosphoramidate,succinic acid,arynes(1,2-substituted arenes)
=== 1,2,3,4-tetrahydroisoquinolines (N-substituted benzoxazole) derivatives === 
==== 4,7-dichloroquinoline ====
* Psychotropic alkylamines induced '''dermatitis''' -> [http://www.sigmaaldrich.com/catalog/product/aldrich/d74002?lang=en&region=SE 4,7-dichloroquinoline]
** Airborne agents causing reaction with micro wave irradiation? (ie: a wireless connection)
** An anti-malarial compound? (quinoline)
** NMDA antagonist?
** See http://www.ncbi.nlm.nih.gov/pubmed/6213361
** http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1982.tb04215.x/abstract
** http://blogs.ch.cam.ac.uk/pmr/files/2012/12/121712_1039_AMI2Content5.png
*** see http://blogs.ch.cam.ac.uk
*** see [http://loinen.i2p.to/rhodium/chemistry/future_drugs.html Future Synthetic Drugs of Abuses]
==== Taking the Yb(OTf)3 road to Sandy Hook ====
* [[User:Etienne Robillard|Etienne Robillard]] 11:18, 19 January 2013 (EST) Also interesting, '''[http://www.sciencedirect.com/science/article/pii/S0040402005005016 microwave-triggered] disubstituted oxadiazoles''' derivatives for psychotropic alkylamine catalysis using '''Yb(OTf)3'''.
* <s>[[User:Etienne Robillard|Etienne Robillard]] 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into [http://www.thesynapticleap.org/node/328 aromatic heterocycle ring systems] in a reaction known as [http://www.openwetware.org/wiki/Todd:Asymmetric_Hydrogenation_of_PZQ_Enamide asymmetric hydrogenation]. See also [[Carboxamide]], a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur.  [Related: [https://en.wikipedia.org/wiki/Asymmetric_hydrogenation 1], Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]</s>
* [[User:Etienne Robillard|Etienne Robillard]] 11:07, 22 January 2013 (EST) '''Hence, did neuroscience student James Holmes took anti-malarial drug before opening fire in Sandy Hook theater and commiting mass murder of Afghanistan childrens?'''
** [[User:Etienne Robillard|Etienne Robillard]] 11:07, 22 January 2013 (EST) In my understanding, the evidences for '''microwave-triggered (MW) peptide synthesis''' may provide to crime-scene investigators (CSI) additional evidences to confirm the role of '''Yb(OTf)3''' as an important factor (organocatalyst) in gold-mediated nanoparticles '''drug delivery''', thus a poorly-documented portrait of synthetic biology may emerge in the understanding of common denominators corroborated from theses cases of recent gun shooting into civilian, gun-free zones (schools, theaters, malls, etc).
* [[User:Etienne Robillard|Etienne Robillard]] 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze '''Yb(OTf)3-mediated substrate''' (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?
==== C-(2-phenoxy)-pyrimidine derived alkylamine ====
* benzaldehyde acetals (3 components ketone/amine acetals with aryl moeity.. hell..secondary aldimine mean R3 is not substituted with H atom but with N atom..thus an aryl or alkyl group=R3..)
* a type of imine [SCHIFF BASE]
=== Glycine/Serine based alternative NMDA inhibitors ===
* doi: 10.1124/mol.108.049312
* keywords: glycine, GlyT1, benzamide, oxidative sulfoxide (oxo), piperazine, schizophrenia
* GlyT-1 = alicyclic conformation (chair) at the piperazine ring ?
* 6-membered ring system = cyclohexane, clozapine, olanzapine, imatinib (source is [http://en.wikipedia.org/wiki/Piperazine#Piperazine_derivatives_as_drugs here].)
* 30C6HSL = methylotroph ?
== See also ==
* http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2
* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
* http://www.cbc.ca/news/canada/story/2012/04/10/malaria-drug-mefloquine.html
* http://alpha.chem.umb.edu/chemistry/ch471/documents/Microwave_Assisted_Peptide_Synthesis.pdf
* [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Imine (Schiff base) formation] [IMINE, IMIDE, SCHIFF_BASE, NUCLEOPHILIC_CARBONYL_ADDITION]
* [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch17/ch17-3-4-2.html Reactions of Alcohols to give Acetals] : <font color=purple>C=O+2ROH</font>
* '''1,2,3,4-tetrahydroisoquinolines derivatives''': http://www.faqs.org/patents/app/20090023728 [AHL, ETHANAMINE, 30C6HSL, SERINE]
* <font color=purple style="background:#ddd">'''Prep of cyclohexyl isocyanide (methyl) reagents (-rn=C) via Hofmann/Ugi route'''</font> http://www.orgsyn.org/orgsyn/prep.asp?prep=cv5p0300
== Dedication ==
This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised
murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -[[User:Etienne Robillard|Etienne Robillard]] 09:50, 20 December 2012 (EST)
== References ==
* Reference 1
* Reference 2
* 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
* Benzaldehyde acetals and secondary aldimines as auxiliary amine catalysts, C(2)phenoxy-pyrimidine type herbicides (diphenamide):  US5178662, US4985066
* [http://www.faqs.org/patents/app/20090099213 Ortho-Condensed Pyridine and Pyrimidine Derivatives (e.g., Purines) as Protein Kinases Inhibitors] (2009)
== Bibliography ==
#Rueping-Boris-J-Nachtsheim-Beilstein-J-Org-Chem-2010 pmid=20485588
== Glossary ==
* Aldimine (primary, secondary) : a specific subtype of imine derived from aldehydes, '''where in the primary form, the aniomeric center is an hydroxyl (H) molecule and in the secondary form a alkyl or aryl adduct is formed (aka a [[Schiff_base|Schiff base]]).'''
* Acetal
* [[User:Etienne_Robillard/Notebook/Acetaldehyde|Acetaldehyde]]
** The same thing as a aldehyde, but apparently a branched alcohol specific species. (See "Acetal" above and "Formaldehyde"). Also known as a "ethanal". 
* Aldehyde: See Acetaldehyde
* Benzaldehyde
* Alkyloid : A N-alkyl derived [[carbene]] (NHC) or non-specific DNA alkylating agent. See also [[Imidazole]] and [[NH2]].
* Branched alcohol: See "Aldehyde"
* Carbylamine: A cyanogenic conjugated primary amine to an hydroxyl group. Sometime named a "Isonitrile" or [http://en.m.wikipedia.org/wiki/Isonitrile#Synthesis_of_isocyanides "Isocyanide"]. 
* Enamine : When a enolate is conjugated to a 2-cyanoethyl cross-linker (ie [[Acetonitrile]] or [[PVA]] or [[PVOH]]), see [[Ethanamine]], the tautomeric form of a ketone-enol imine.
* Imide: See http://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/aldket1.htm
* Imine: The '''tautomeric form''' (functional group) of chiral enatiomers with one C=N double bond.
* Isonitrile: The same thing as Carbylamine
* Formaldehyde:
* FRET: Fluorescence Resonance Energy Transfer
* Ketone: See http://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/aldket1.htm
* Ring Systems http://www.chem.qmul.ac.uk/iupac/class/rings.html
* Nitrogen  http://www.chem.qmul.ac.uk/iupac/class/oneN.html
* PVA (Polyvinyl Alcohol): a  chiral reagent for benzaldehyde acetals like reflux reactions comparable to acetonitrile... Thus an '''acetal'''dehyde derived compound...
* Schiff base
* Yb(OTf)3

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