Difference between revisions of "User:Etienne Robillard/Notebook/Arylcyclohexylamines"

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== Introduction ==
Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of schizophrenia and
autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.
The purpose of this document is to investigate the whys and wherefores of Agent Scooby Doo in the product of cyclohexylamine induced reactions
by comparitive study of psychotropic alkylamines drugs including Methylphenidate and Arylacetonitriles-derived alkylating solvents and their combined effects on
human NMDA receptor.
Also the study of PCP derived piperidine analog compounds will be beneficial in the proper understanding of synthetic drug abuses and
to prevent future disasters by chemical aerosol spraying prohibition and legislation.
== Psychotropic alkylamines ==
=== cyclohexylamines, methamphetamine, and methylphenidate ===
==== Methylphenidate (Ritalin) ====
Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by
the scientific community. [[http://en.wikipedia.org/wiki/Methylphenidate#Long-term_effects 1]]
Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in
chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy
of childrens with amphetamine-like drugs.  [[http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html 2]]
Amphetamine-induced psychosis may implicate as well severe hallucinations and other landmarks of long-term
drug abuses including altered state of behavior, paranoia, and depression.
=== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides  ===
* Documentation:
** http://en.wikipedia.org/wiki/Phase-transfer_catalysis
** http://en.wikipedia.org/wiki/Amide
** http://euch6f.chem.emory.edu/arynes.html
** [http://www.chemguide.co.uk/organicprops/anhydrides/nitrogen.html Reactions of Ketones with Primary Amines]
** http://research.cm.utexas.edu/nbauld/CHAPTER%2021.htm
==== Arylcyclohexylamines and N-substituted cyclohexylaminopyrimidines derivatives ====
* Aryl ketones (4-trans substituted cyclohexylamines and 4-methoxy derived compounds)
** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
* "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
* "phosphines" and the [[Phosphohistidine_transferase|phosphohistidine transferase]] enzyme.
** phosphoramidate based peptide and oligo "coupling" reagents...
* N-substituted cyclohexylaminopyrimidines:
** E. coli K-12 W3110 (aka the pyrimidine starved strain...)
** [http://openwetware.org/wiki/OSDDMalaria:GSK_Amino-thienopyrimidine_Series GSK Amino thienopyrimidine series]
*** See US5039692 - Psychotropic phenoxyalkylamine derivatives (1,2-substituted thienopyrimidone)
* Keywords:
** cyanoethylation,arylcyclohexylamine,phosphoramidate,succinic acid,arynes(1,2-substituted arenes)
==== 4,7-dichloroquinoline ====
* Psychotropic alkylamines induced '''dermatitis''' -> [http://www.sigmaaldrich.com/catalog/product/aldrich/d74002?lang=en&region=SE 4,7-dichloroquinoline]
** Airborne agents causing reaction with micro wave irradiation? (ie: a wireless connection)
** An anti-malarial compound? (quinoline)
** NMDA antagonist?
** See http://www.ncbi.nlm.nih.gov/pubmed/6213361
** http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1982.tb04215.x/abstract
** http://blogs.ch.cam.ac.uk/pmr/files/2012/12/121712_1039_AMI2Content5.png
*** see http://blogs.ch.cam.ac.uk
*** see [http://loinen.i2p.to/rhodium/chemistry/future_drugs.html Future Synthetic Drugs of Abuses]
== See also ==
* http://en.wikipedia.org/wiki/Amphetamine
* http://en.wikipedia.org/wiki/Methamphetamine
* http://en.wikipedia.org/wiki/Methylphenidate
* http://en.wikipedia.org/wiki/Methoxetamine
* http://en.wikipedia.org/wiki/Piperidine
* http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2
* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
== Dedication ==
This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised
murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -[[User:Etienne Robillard|Etienne Robillard]] 09:50, 20 December 2012 (EST)
== References ==
* Reference 1
* Reference 2
* 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
== Glossary ==
* Ring Systems http://www.chem.qmul.ac.uk/iupac/class/rings.html
* Nitrogen  http://www.chem.qmul.ac.uk/iupac/class/oneN.html

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