Difference between revisions of "User:Etienne Robillard/Notebook/Arylcyclohexylamines"

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(N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides)
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== Introduction ==
 
 
 
Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of schizophrenia and
 
autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.
 
 
 
The purpose of this document is to investigate the whys and wherefores of Agent Scooby Doo in the product of cyclohexylamine induced reactions
 
by comparitive study of psychotropic alkylamines drugs including Methylphenidate and Arylacetonitriles-derived alkylating solvents and their combined effects on
 
human NMDA receptor.
 
 
 
Also the study of PCP derived piperidine analog compounds will be beneficial in the proper understanding of synthetic drug abuses and
 
to prevent future disasters by chemical aerosol spraying prohibition and legislation.
 
 
 
== Psychotropic alkylamines ==
 
 
 
=== Cyclohexylamines, methamphetamine, and methylphenidate ===
 
 
 
==== Methylphenidate (Ritalin) ====
 
 
 
Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
 
regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by
 
the scientific community. [[http://en.wikipedia.org/wiki/Methylphenidate#Long-term_effects 1]]
 
 
 
Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in
 
chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy
 
of childrens with amphetamine-like drugs.  [[http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html 2]]
 
 
 
Amphetamine-induced psychosis may implicate as well severe hallucinations and other landmarks of long-term
 
drug abuses including altered state of behavior, paranoia, and depression.
 
 
 
==== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides ====
 
 
 
* Documentation:
 
** http://en.wikipedia.org/wiki/Phase-transfer_catalysis
 
** http://en.wikipedia.org/wiki/Amide
 
** http://euch6f.chem.emory.edu/arynes.html
 
** [http://www.chemguide.co.uk/organicprops/anhydrides/nitrogen.html Reactions of Ketones with Primary Amines]
 
** http://research.cm.utexas.edu/nbauld/CHAPTER%2021.htm
 
 
 
* See also:
 
** Aryl ketones (4-trans substituted cyclohexylamines and 4-methoxy derived compounds)
 
** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
 
** "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
 
 
 
* Keywords:
 
** cyanoethylation,arylcyclohexylamine,phosphoramidate,succinic acid,arynes
 
 
 
==== 4,7-dichloroquinoline ====
 
 
 
* Psychotropic alkylamines induced '''dermatitis''' -> [http://www.sigmaaldrich.com/catalog/product/aldrich/d74002?lang=en&region=SE 4,7-dichloroquinoline]
 
** Airborne agents causing reaction with micro wave irradiation? (ie: a wireless connection)
 
** An anti-malarial compound? (quinoline)
 
** NMDA antagonist?
 
** See http://www.ncbi.nlm.nih.gov/pubmed/6213361
 
** http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1982.tb04215.x/abstract
 
** US Patent Application: 20110281844 ("NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS")
 
** http://blogs.ch.cam.ac.uk/pmr/files/2012/12/121712_1039_AMI2Content5.png
 
*** see http://blogs.ch.cam.ac.uk
 
*** see [http://loinen.i2p.to/rhodium/chemistry/future_drugs.html Future Synthetic Drugs of Abuses]
 
== See also ==
 
 
 
* http://en.wikipedia.org/wiki/Amphetamine
 
* http://en.wikipedia.org/wiki/Methamphetamine
 
* http://en.wikipedia.org/wiki/Methylphenidate
 
* http://en.wikipedia.org/wiki/Methoxetamine
 
* http://en.wikipedia.org/wiki/Piperidine
 
* http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2
 
* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
 
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
 
 
 
== Dedication ==
 
 
 
This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised
 
murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -[[User:Etienne Robillard|Etienne Robillard]] 09:50, 20 December 2012 (EST)
 
 
 
== References ==
 
 
 
* Reference 1
 
* Reference 2
 
* US patents :
 
** 4-substituted Arylcyclohexylamines derived compounds :
 
*** US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
 
 
 
== Glossary ==
 
 
 
* Ring Systems http://www.chem.qmul.ac.uk/iupac/class/rings.html
 
* Nitrogen  http://www.chem.qmul.ac.uk/iupac/class/oneN.html
 
 
 
[[Category:Chemical]]
 
[[Category:Psychochemical]]
 

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