User:Elena Sineva

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Revision as of 07:10, 6 August 2013 by Elena Sineva (talk | contribs) (Publications)

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Contact Info

Elena Sineva (an artistic interpretation)
  • Elena Sineva
  • The Pennsylvania State University
  • Biochemistry and Molecular Biology
  • 107 Althouse Laboratory

University Park, PA 16802

I work at Pennsylvania State University. I learned about OpenWetWare from, and I've joined because wish to store some of my protocols, sequences and data.


  • 2001, PhD, Bar Ilan University, Israel
  • Year, MS, Dnepropetrovsk State University, Ukraine

Research interests

  1. Interest 1
  2. Interest 2
  3. Interest 3


  1. Davydov DR, Davydova NY, Sineva EV, Kufareva I, and Halpert JR. Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone. Biochem J. 2013 Jul 15;453(2):219-30. DOI:10.1042/BJ20130398 | PubMed ID:23651100 | HubMed [Paper1]
  2. Davydov DR, Sineva EV, Davydova NY, Bartlett DH, and Halpert JR. CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450. Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):30-40. DOI:10.1002/bab.1083 | PubMed ID:23586990 | HubMed [Paper2]
  3. Sineva E, Shadrin A, Rodikova EA, Andreeva-Kovalevskaya ZI, Protsenko AS, Mayorov SG, Galaktionova DY, Magelky E, and Solonin AS. Iron regulates expression of Bacillus cereus hemolysin II via global regulator Fur. J Bacteriol. 2012 Jul;194(13):3327-35. DOI:10.1128/JB.00199-12 | PubMed ID:22522892 | HubMed [Paper3]
  4. Davydov DR, Rumfeldt JA, Sineva EV, Fernando H, Davydova NY, and Halpert JR. Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET). J Biol Chem. 2012 Feb 24;287(9):6797-809. DOI:10.1074/jbc.M111.325654 | PubMed ID:22194603 | HubMed [Paper4]
  5. Srivastava A, Talaue M, Liu S, Degen D, Ebright RY, Sineva E, Chakraborty A, Druzhinin SY, Chatterjee S, Mukhopadhyay J, Ebright YW, Zozula A, Shen J, Sengupta S, Niedfeldt RR, Xin C, Kaneko T, Irschik H, Jansen R, Donadio S, Connell N, and Ebright RH. New target for inhibition of bacterial RNA polymerase: 'switch region'. Curr Opin Microbiol. 2011 Oct;14(5):532-43. DOI:10.1016/j.mib.2011.07.030 | PubMed ID:21862392 | HubMed [Paper5]
  6. Yakhnin H, Yakhnin AV, Baker CS, Sineva E, Berezin I, Romeo T, and Babitzke P. Complex regulation of the global regulatory gene csrA: CsrA-mediated translational repression, transcription from five promoters by Eσ⁷⁰ and Eσ(S), and indirect transcriptional activation by CsrA. Mol Microbiol. 2011 Aug;81(3):689-704. DOI:10.1111/j.1365-2958.2011.07723.x | PubMed ID:21696456 | HubMed [Paper6]
  7. Sineva EV and Davydov DR. Cytochrome P450 from Photobacterium profundum SS9, a piezophilic bacterium, exhibits a tightened control of water access to the active site. Biochemistry. 2010 Dec 21;49(50):10636-46. DOI:10.1021/bi101466y | PubMed ID:21082780 | HubMed [Paper7]
  8. Sineva EV and Davydov DR. Constrained water access to the active site of cytochrome P450 from the piezophilic bacterium Photobacterium profundum. High Press Res. 2010 Dec 1;30(4):466-474. DOI:10.1080/08957959.2010.535208 | PubMed ID:21475616 | HubMed [Paper8]
  9. Teplova VV, Andreeva-Kovalevskaya ZI, Sineva EV, and Solonin AS. Quick assessment of cytotoxins effect on Daphnia magna using in vivo fluorescence microscopy. Environ Toxicol Chem. 2010 Jun;29(6):1345-8. DOI:10.1002/etc.169 | PubMed ID:20821578 | HubMed [Paper9]
  10. Davydov DR, Sineva EV, Sistla S, Davydova NY, Frank DJ, Sligar SG, and Halpert JR. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochim Biophys Acta. 2010 Mar;1797(3):378-90. DOI:10.1016/j.bbabio.2009.12.008 | PubMed ID:20026040 | HubMed [Paper10]
  11. Sineva EV, Andreeva-Kovalevskaya ZI, Shadrin AM, Gerasimov YL, Ternovsky VI, Teplova VV, Yurkova TV, and Solonin AS. Expression of Bacillus cereus hemolysin II in Bacillus subtilis renders the bacteria pathogenic for the crustacean Daphnia magna. FEMS Microbiol Lett. 2009 Oct;299(1):110-9. DOI:10.1111/j.1574-6968.2009.01742.x | PubMed ID:19686345 | HubMed [Paper11]
  12. Andreeva-Kovalevskaya ZhI, Solonin AS, Sineva EV, and Ternovsky VI. Pore-forming proteins and adaptation of living organisms to environmental conditions. Biochemistry (Mosc). 2008 Dec;73(13):1473-92. PubMed ID:19216713 | HubMed [Paper12]
  13. Pavlova O, Mukhopadhyay J, Sineva E, Ebright RH, and Severinov K. Systematic structure-activity analysis of microcin J25. J Biol Chem. 2008 Sep 12;283(37):25589-95. DOI:10.1074/jbc.M803995200 | PubMed ID:18632663 | HubMed [Paper13]
  14. Lapouge K, Sineva E, Lindell M, Starke K, Baker CS, Babitzke P, and Haas D. Mechanism of hcnA mRNA recognition in the Gac/Rsm signal transduction pathway of Pseudomonas fluorescens. Mol Microbiol. 2007 Oct;66(2):341-56. DOI:10.1111/j.1365-2958.2007.05909.x | PubMed ID:17850261 | HubMed [Paper14]
  15. Andreeva ZI, Nesterenko VF, Fomkina MG, Ternovsky VI, Suzina NE, Bakulina AY, Solonin AS, and Sineva EV. The properties of Bacillus cereus hemolysin II pores depend on environmental conditions. Biochim Biophys Acta. 2007 Feb;1768(2):253-63. DOI:10.1016/j.bbamem.2006.11.004 | PubMed ID:17173854 | HubMed [Paper15]
  16. Andreeva ZI, Nesterenko VF, Yurkov IS, Budarina ZI, Sineva EV, and Solonin AS. Purification and cytotoxic properties of Bacillus cereus hemolysin II. Protein Expr Purif. 2006 May;47(1):186-93. DOI:10.1016/j.pep.2005.10.030 | PubMed ID:16380268 | HubMed [Paper16]
  17. Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD Jr, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, Ebright RH, and Arnold E. Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell. 2005 Aug 26;122(4):541-52. DOI:10.1016/j.cell.2005.07.017 | PubMed ID:16122422 | HubMed [Paper17]
  18. Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, and Cameron CE. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif. 2004 Sep;37(1):144-53. DOI:10.1016/j.pep.2004.05.005 | PubMed ID:15294292 | HubMed [Paper18]
  19. Mukhopadhyay J, Sineva E, Knight J, Levy RM, and Ebright RH. Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel. Mol Cell. 2004 Jun 18;14(6):739-51. DOI:10.1016/j.molcel.2004.06.010 | PubMed ID:15200952 | HubMed [Paper19]
  20. Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, and Ebright RH. Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot. J Am Chem Soc. 2003 Oct 15;125(41):12382-3. DOI:10.1021/ja036677e | PubMed ID:14531661 | HubMed [Paper20]
  21. Shapiro YE, Sinev MA, Sineva EV, Tugarinov V, and Meirovitch E. Backbone dynamics of escherichia coli adenylate kinase at the extreme stages of the catalytic cycle studied by (15)N NMR relaxation. Biochemistry. 2000 Jun 6;39(22):6634-44. PubMed ID:10828981 | HubMed [Paper21]
  22. Sinev M, Landsmann P, Sineva E, Ittah V, and Haas E. Design consideration and probes for fluorescence resonance energy transfer studies. Bioconjug Chem. 2000 May-Jun;11(3):352-62. PubMed ID:10821651 | HubMed [Paper22]
  23. Meirovitch E, Sinev MA, and Sineva EV. Sequence-specific 1H, 15N and 13C assignment of adenylate kinase from Escherichia coli in complex with the inhibitor AP5A. J Biomol NMR. 1999 Feb;13(2):195-6. PubMed ID:10070761 | HubMed [Paper23]
  24. Den'mukhametov MM, Zakharova MV, Kravets AN, Pertsev AV, Sineva EV, Repik AV, Beletskaia IV, Gromova ES, and Solonin AS. [Characteristics of a plasmid bearing a gene of a restriction modification type II system--the SsoII isoschizomer]. Mol Biol (Mosk). 1997 Sep-Oct;31(5):831-8. PubMed ID:9454069 | HubMed [Paper24]
  25. Sinev MA, Sineva EV, Ittah V, and Haas E. Towards a mechanism of AMP-substrate inhibition in adenylate kinase from Escherichia coli. FEBS Lett. 1996 Nov 18;397(2-3):273-6. PubMed ID:8955362 | HubMed [Paper25]
  26. Sinev MA, Sineva EV, Ittah V, and Haas E. Domain closure in adenylate kinase. Biochemistry. 1996 May 21;35(20):6425-37. DOI:10.1021/bi952687j | PubMed ID:8639589 | HubMed [Paper26]
  27. Sineva EV, Zakharova GG, Tarutina ZE, Kravets AN, and Solonin AS. [Restriction system--type II modification in Enterobacter cloacae strains]. Mol Gen Mikrobiol Virusol. 1993 Sep-Oct(5):10-3. PubMed ID:8289838 | HubMed [Paper27]
  28. Kravetz AN, Zakharova MV, Beletskaya IV, Sineva EV, Denjmuchametov MM, Petrov SI, Glatman LI, and Solonin AS. The cleavage sites and localization of genes encoding the restriction endonucleases Eco1831I and EcoHI. Gene. 1993 Jul 15;129(1):153-4. PubMed ID:8335254 | HubMed [Paper28]

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  29. ISBN:0879697164 [Book1]

All Medline abstracts: PubMed | HubMed

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